FRDA_MOUSE O35943
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UniProt:O35943
Recommended name：Frataxin, mitochondrial
EC number：EC 1.16.3.1
Alternative names：(Fxn)
Cleaved into：Frataxin intermediate form; Frataxin mature form
GeneID：14297
Gene names (primary )：Fxn
Gene names (synonym )：Frda
Gene names (ORF )：
Length：207
Mass：22924
Sequence：MWAFGGRAAVGLLPRTASRASAWVGNPRWREPIVTCGRRGLHVTVNAGATRHAHLNLHYLQILNIKKQSVCVVHLRNLGTLDNPSSLDETAYERLAEETLDSLAEFFEDLADKPYTLEDYDVSFGDGVLTIKLGGDLGTYVINKQTPNKQIWLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLARELTKALNTKLDLSSLAYSGKGT
Tissue specificity：Heart, liver, skeletal muscle, kidney, spleen and thymus. Weakly expressed in the brain and lung. {ECO:0000269|PubMed:9241270}.
Induction：
Developmental stage：Expression in the ventricular zone which corresponds to dividing neuronal precursors begins at day 12.5, increases during embryonic development and persists at postnatal day 7 (P7) in the ependymal layer, which is the remnant of the ventricular zone. Weak expression seen in the spinal cord and medulla oblongata, starting at 14.5 dpc and expression also observed in dorsal root ganglia, starting at 14.5 dpc. At P14, expression in the dorsal root ganglia is restricted to the cortical region where the sensory neuron cell bodies are located. In non-neural tissues strong expression seen in the developing liver from 10.5 dpc. Expression detected in the heart and in the cortex of the developing kidney at 12.5 dpc and later. Very high expression observed in the brown adipose tissue. Expression seen in small islands around the neck and back at 14.5 dpc, then in large masses at 16.5 dpc and 18.5 dpc and at P14 is absent in brown adipose tissue. Expression also seen in the thymus and developing gut at 14.5 dpc and until postnatal life. At P14, expression in thymus is restricted to the proliferating cells in the cortical zone and is also prominent in the spleen. Found in the lung at 14.5 dpc. {ECO:0000269|PubMed:9241270}.
Protein families：Frataxin family