MTP_MOUSE O08601
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UniProt:O08601
Recommended name：Microsomal triglyceride transfer protein large subunit
EC number：
Alternative names：
Cleaved into：
GeneID：17777
Gene names (primary )：Mttp
Gene names (synonym )：Mtp
Gene names (ORF )：
Length：894
Mass：99099
Sequence：MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGKPQDSVGYKISSDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKSIFQGKSTPKIIGKDNLEALQRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVSSKATSVTTYKIEDSFVTAVLAEETRAFALNFQQTIAGKIVSKQKLELKTTEAGPRMIPGKQVAGVIKAVDSKYKAIPIVGQVLERVCKGCPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPDSLEAILDFLDFKSDSSIILQERFLYACGFATHPDEELLRALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDVSFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNPSYMDVKNILLSIGELPKEMNKYMLTVVQDILHFEMPASKMIRRVLKEMAVHNYDRFSKSGSSSAYTGYVERSPRAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKANMEIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDVTVDASFVKAGVESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRRRKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF
Tissue specificity：[Isoform 1]: Mainly expressed in the intestine and the liver, and at lower levels in white and brown fat cells (PubMed:17635917, PubMed:8660984). Expressed in heart (PubMed:9502759). {ECO:0000269|PubMed:17635917, ECO:0000269|PubMed:8660984, ECO:0000269|PubMed:9502759}.; [Isoform 2]: Ubiquitous, and is the major isoform in hematopoietic cells and adipocytes. {ECO:0000269|PubMed:17312007, ECO:0000269|PubMed:17635917}.
Induction：Up-regulated by FOXO1. Expressed in a circadian manner in the liver. {ECO:0000269|PubMed:18497885, ECO:0000269|PubMed:24353284}.
Developmental stage：Expression in the yolk sac tissues followed by expression in the primordial liver cell nests as early as day 9 post-coitum (9.5 dpc). Intestinal expression is detected around 12.5 dpc and attains full adult expression patterns by 14.5 dpc. {ECO:0000269|PubMed:10744773}.
Protein families：