CEAM1_MOUSE P31809
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UniProt:P31809
Recommended name：Carcinoembryonic antigen-related cell adhesion molecule 1
EC number：
Alternative names：(Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
Cleaved into：
GeneID：26365
Gene names (primary )：Ceacam1
Gene names (synonym )：Bgp Bgp1
Gene names (ORF )：
Length：521
Mass：57016
Sequence：MELASAHLHKGQVPWGGLLLTASLLASWSPATTAEVTIEAVPPQVAEDNNVLLLVHNLPLALGAFAWYKGNTTAIDKEIARFVPNSNMNFTGQAYSGREIIYSNGSLLFQMITMKDMGVYTLDMTDENYRRTQATVRFHVHPILLKPNITSNNSNPVEGDDSVSLTCDSYTDPDNINYLWSRNGESLSEGDRLKLSEGNRTLTLLNVTRNDTGPYVCETRNPVSVNRSDPFSLNIIYGPDTPIISPSDIYLHPGSNLNLSCHAASNPPAQYFWLINEKPHASSQELFIPNITTNNSGTYTCFVNNSVTGLSRTTVKNITVLEPVTQPFLQVTNTTVKELDSVTLTCLSNDIGANIQWLFNSQSLQLTERMTLSQNNSILRIDPIKREDAGEYQCEISNPVSVRRSNSIKLDIIFDPTQGGLSDGAIAGIVIGVVAGVALIAGLAYFLYSRKSGGGSDQRDLTEHKPSTSNHNLAPSDNSPNKVDDVAYTVLNFNSQQPNRPTSAPSSPRATETVYSEVKKK
Tissue specificity：Expressed in granulocytes, lymphocytes, granulocytes, B cells, and T-cells (PubMed:11994468). Expressed in bone. Highly expressed in liver and femur (PubMed:25490771). Highly expressed in neutrophils, and to a lesser extent inmonocytes, and macrophages. Slightly higher expressed in peripheral blood neutrophils (PBNs) (PubMed:21029969). Intestinal T-cells predominantly express isoform 2 while extraintestinal T-cells mainly express isoform 1 (PubMed:23123061). Expressed in small intestine and colon (PubMed:25908210). {ECO:0000269|PubMed:11994468, ECO:0000269|PubMed:21029969, ECO:0000269|PubMed:23123061, ECO:0000269|PubMed:25490771, ECO:0000269|PubMed:25908210}.
Induction：In intestinal epithelium, up-regulated in the presence of Gram-positive commensal gut bacteria (PubMed:25908210). May also be up-regulated by interferon gamma (IFNG) and TNF (TNF-alpha) (PubMed:25908210). Isoform 2: Expression is promoted and maintained by the mucosal environment (PubMed:23123061). Induced by IL2 on natural killer cell (PubMed:23696226). {ECO:0000269|PubMed:23123061, ECO:0000269|PubMed:23696226, ECO:0000269|PubMed:25908210}.
Developmental stage：Expression increases during the early stages of osteoblast differentiation, and decreases towards terminal osteoblast differentiation. In addition, expression markedly decreases during the course of osteoclastogenesis. {ECO:0000269|PubMed:25490771}.
Protein families：Immunoglobulin superfamily, CEA family