ELF3_MOUSE Q3UPW2
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UniProt:Q3UPW2
Recommended name：ETS-related transcription factor Elf-3
EC number：
Alternative names：(E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)
Cleaved into：
GeneID：13710
Gene names (primary )：Elf3
Gene names (synonym )：Ert Esx Jen
Gene names (ORF )：
Length：391
Mass：44273
Sequence：MAATCEISNVFSNYFNAMYSSEDPTLAPAPPTTFGTEDLVLTLNNQQMTLEGPGPQTRSQRDRTDPLAVLHLAEKASWTSERPQFWSKTQVLEWISYQVEKNKYDASSIDFSRCDMDGATLCSCALEELRLVFGPLGDQLHAQLRDLTSNSSDELSWIIELLEKDGMSFQESLGDSGPFDQGSPFAQELLDDGRQASPYYCSTYGPGAPSPGSSDVSTARTATPQSSHASDSGGSDVDLDLTESKVFPRDGFPDYKKGEPKHGKRKRGRPRKLSKEYWDCLEGKKSKHAPRGTHLWEFIRDILIHPELNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNSSGWKEEEVGESRN
Tissue specificity：Expressed in small intestine, colon, lung, kidney and uterus. Also expressed in the corneal epithelium and conjunctiva of the developing and adult eye. Not detected in liver, spleen, thymus, brain, heart, skeletal muscle or ovary. {ECO:0000269|PubMed:11025204, ECO:0000269|PubMed:9395241}.
Induction：Expression in HC11 cells from midpregnant mouse mammary epithelium increases upon reaching lactogenic competency, and is down-regulated upon exposure to lactogenic hormones that induce milk protein (Beta-casein) expression. Up-regulated upon differentiation in corneal epithelium. {ECO:0000269|PubMed:11025204, ECO:0000269|PubMed:9806763}.
Developmental stage：Expression increases progressively from 7 dpc and is detectable in virgin mammary glands, then shows little if any change during pregnancy and declines to barely detectable levels after 3 days of lactation. Detected from 13.5 dpc in conjunctiva epithelium. In cornea, a weak signal is detected at 16.5 dpc and persists throughout the later stages of development. {ECO:0000269|PubMed:11025204, ECO:0000269|PubMed:9806763}.
Protein families：ETS family