LIN41_MOUSE Q1PSW8
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UniProt:Q1PSW8
Recommended name：E3 ubiquitin-protein ligase TRIM71
EC number：EC 2.3.2.27
Alternative names：(Protein lin-41 homolog) (mLin41) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
Cleaved into：
GeneID：636931
Gene names (primary )：Trim71
Gene names (synonym )：Gm1127 Lin41
Gene names (ORF )：
Length：855
Mass：92054
Sequence：MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSAGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAPGGAGPAEALKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATAEEPPPKNGRAGGGPGGAGGHSNHRHHAHHPAQRAAAPAPQPPPGPAASPGSLLMRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQLLADAQQGRQALQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEDRECELLWKVEKIRQVKAKSLFLQVEKLRQSLSKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRIMFTPPDQALYLALKSIGFVSSGAFAPLTKATGDGIKRALQGKVASFTVMGYDHDGEPRHSGGDLMSVVVLGPDGNLFGAEVSDQQNGTYIVSYRPQLEGEHLVSVTLYNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDGEGKLCRPWGVSVDKEGFIIVADRSNNRIQVFKPCGSFHHKFGTLGSRPGQFDRPAGVACDASRRIIVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFDSPRGVAFNNEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGSGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFEANGSFLCKFGAQGSGFGQMDRPSGIAVTPDGLIVVVDFGNNRILIF
Tissue specificity：Highly expressed in undifferentiated embryonic stem cells (ESCs). Expressed in the epiblast and in interfollicular epidermal stem cells during early development. Also expressed in male germ cells and in the reproductive tract. Highly expressed in neuroepithelial cells, and its expression declines as neurogenesis proceeds (at protein level). Expressed in ependymal cells of the brain (PubMed:25883935). {ECO:0000269|PubMed:19898466, ECO:0000269|PubMed:22508726, ECO:0000269|PubMed:22735451, ECO:0000269|PubMed:25883935}.
Induction：Negatively regulated by the microRNA (miRNA) let-7 which causes degradation of the mRNA encoding this protein. This requires a let-7 complementary site (LCS) in the 3'-UTR of the mRNA encoding this protein. {ECO:0000269|PubMed:22735451}.
Developmental stage：Expression is first detected at 8.5 dpc, increases to highest levels at 14.5 dpc and remains elevated through the newborn stage. Expressed in developing limb buds and tail buds starting from 9.5 dpc. At 9.5 dpc, expression is prominent in the entire embryo, with the exception of the primordial cardiac sac. At 10.5 dpc, expression reduces to the neuroepithelium, branchial arches, spinal cord, somites, limb, and tail buds. At the onset of central nervous system development, the neuroepithelium shows a prominent staining between 9.5 dpc and 10.5 dpc. Thereafter, expression is unevenly distributed in a progressively thinner layer along the inner surface of the ventricle. Expression is intense at the bumps corresponding to the nascent limb buds around 10.5 dpc. Shortly thereafter, as the limb buds emerge from the body and expand, expression declines and is limited to the most distal surface at 12.5 dpc. At 13.5 dpc it is no longer possible to identify expression in either the developing nervous system, the limb or the tail buds. From postnatal day 10 (P10) to the adulthood, expressed in cells lining the wall of the four ventricles of the postnatal brain (PubMed:25883935). {ECO:0000269|PubMed:16247770, ECO:0000269|PubMed:16477647, ECO:0000269|PubMed:25883935}.
Protein families：TRIM/RBCC family