APRV1_MOUSE Q09PK2
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UniProt:Q09PK2
Recommended name：Retroviral-like aspartic protease 1
EC number：EC 3.4.23.-
Alternative names：(Skin-specific retroviral-like aspartic protease) (SASPase) (Skin aspartic protease) (TPA-inducible aspartic proteinase-like protein)
Cleaved into：
GeneID：67855
Gene names (primary )：Asprv1
Gene names (synonym )：Sasp Taps
Gene names (ORF )：
Length：339
Mass：37174
Sequence：MRNPGGPGWASKRPLQKKQNTACLCAQQPARHFVPAPFNSSRQGKNTAQPTEPSLSSVIAPTLFCAFLYLACVTAELPEVSRRMATSGVRSKEGRREHAFVPEPFTGTNLAPSLWLHRFEVIDDLNHWDHATKLRFLKESLKGDALDVYNGLSSQAQGDFSFVKQALLRAFGAPGEAFSEPEEILFANSMGKGYYLKGKVGHVPVRFLVDSGAQVSVVHPALWEEVTDGDLDTLRPFNNVVKVANGAEMKILGVWDTEISLGKTKLKAEFLVANASAEEAIIGTDVLQDHNAVLDFEHRTCTLKGKKFRLLPVGSSLEDEFDLELIEEEEGSSAPEGSH
Tissue specificity：Highly expressed in stratified epithelia in skin, tongue, esophagus, forestomach and vagina. Also expressed in trachea, urinary bladder and thymus. Undetectable in simple epithelia. Within the epidermis, expressed exclusively in the granular layer (at protein level). Levels are elevated in benign skin tumors but are down-regulated in squamous cell carcinomas. {ECO:0000269|PubMed:16565508, ECO:0000269|PubMed:16837463}.
Induction：By 12-O-tetradecanoylphorbol-13-acetate (TPA). No TPA-induced expression is seen in mice lacking Fos. {ECO:0000269|PubMed:16565508}.
Developmental stage：Expression is first detected at embryonic day 15.5. {ECO:0000269|PubMed:16837463}.
Protein families：