NR2E1_MOUSE Q64104
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UniProt:Q64104
Recommended name：Nuclear receptor subfamily 2 group E member 1
EC number：
Alternative names：(Nuclear receptor TLX) (Protein tailless homolog) (Tll) (mTll)
Cleaved into：
GeneID：21907
Gene names (primary )：Nr2e1
Gene names (synonym )：Tll Tlx
Gene names (ORF )：
Length：385
Mass：42619
Sequence：MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEDNGAAAHFPSTALPAPAFFTAVTQLEPHGLELAAVSATPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNTDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
Tissue specificity：Expressed in embryonic developing forebrain and in dorsal midbrain. Outside the neural epithelium only found in the surface ectoderm at the site of nasal placode formation, where subsequently the nasal and olfactory epithelium is formed. Also expressed in adult brain. {ECO:0000269|PubMed:7720587}.
Induction：
Developmental stage：Expression is first detected on 8 dpc and increases until 13.5 dpc, then sharply decreases from day 13 dpc until 18 dpc. Expression is barely detected in newborn brains but increases again after birth. Highly expressed in the retinal neuroblastic layer during the early stages of retinogenesis. Down-regulated during neuronal development. At 14.5 dpc, expressed in the periventricular neural stem cells of the brain. {ECO:0000269|PubMed:17901127, ECO:0000269|PubMed:7720587}.
Protein families：Nuclear hormone receptor family, NR2 subfamily