SORC2_MOUSE Q9EPR5
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UniProt:Q9EPR5
Recommended name：VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain]
EC number：
Alternative names：
Cleaved into：
GeneID：81840
Gene names (primary )：Sorcs2
Gene names (synonym )：
Gene names (ORF )：
Length：1159
Mass：128902
Sequence：MAHRGPPSAPKRPGPTAPDRSFQALLPPCWPRSWPLLLLLLVLVAACGAMGRSPQPGRQGPGVQITRLLPAGRTESGDRKDPQARESEPSVPGLGPGSASGPSTDGAPAPGKGRRARAVPVAGAASASRAQVSLISTSFVLKGDATHNQAMVHWTGENSSVILILTKYYHADMGKVLESSLWRSSDFGTTYTKLTLQPGVTTVIDNFYICPANKRKIILVSSSLGDREQSLFLSTDEGATFQKYPVPFLVEMLLFHPKEEDKVLAYTKDSKLYVSSDLGKKWTLLQERVTKDHVFWAVSGVDDDPNLVHVEAQDLSGGYRYYTCLIYNCSAQPHIAPFSGPIDRGSLTVQDEYIFLKATSTNRTKYYVSYRRSDFVLMKLPKYALPKDLQIISTDEQQVFVAVQEWNQVDTYNLYQSDLRGVRYSLVLENVRSSRQAEENVVIDILEVRGVKGVFLANQKVDGKVTTVITYNKGRDWDYLRPPSTDMNGKPTNCQPPDCYLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHVLYLDHGGVIAAIKDTSIPLKILKFSVDEGHTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISFRSDWELVKVDFRPSFPRQCGEDDYSSWDLTDLQGDHCIMGQQRSYRKRKSTSWCVKGRSFTSALTSRVCKCRDSDFLCDYGFERSSSSESTANKCSANFWFNPLSPPEDCVLGQTYTSSLGYRKVVSNVCEGGVDLQQSPVQLQCPLQAPRGLQVSIRGEAVAVRPREDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHHYESPGIYRVSVRAENMAGHDEAVLFVQVNSPLQALYLEVVPVIGVNQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTKFTDAGDVRVTVQAACGNSVLQDSRLVRVLDQFQVVPLRFSRELDTFNPNTPEWREDVGLVVTRLLSKETSIPEELLVTVVKPGLPTIADLYVLLPLPRPTRKRSLTSDKRLAAVQQALNSHRISFILRGGLRILVELRDTDTGPQRPGGSGGYWAVVVLFVIGLFAVGAFILYKFKRKRPGRTVYAQMHNEKEQEMTSPVSHSEDAQSTMQGNHSGVVLSINSREMHSYLVG
Tissue specificity：Detected in Purkinje cells and pyramidal neurons in brain cortex, cerebellum, dentate gyrus, striatum and hippocampus, and in glia cells in dorsal root ganglia (DRG) (PubMed:24908487, PubMed:27457814, PubMed:28469074, PubMed:30840898). Not detected in neurons from the dorsal root ganglia (PubMed:24908487). Detected in hair cells and supporting cells in the organ of Corti, utricuar maculae and cristae (at protein level) (PubMed:28346477). Detected in brain, lung and testis (PubMed:11165493). Detected in the inner ear in neonates (PubMed:28346477). {ECO:0000269|PubMed:11165493, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:27457814, ECO:0000269|PubMed:28346477, ECO:0000269|PubMed:28469074, ECO:0000269|PubMed:30840898}.
Induction：
Developmental stage：Expression is highest in developing brain. Transiently expressed in all 3 germ layers (PubMed:11165493). Detected in midbrain, spinal cord, heart and lung at 15.5 dpc (PubMed:24908487). Coexpressed with NGFR in neurons in the ventral part of the hippocampus CA1 region at 23 and 30 days after birth. The number of neurons that coexpress SORCS2 and NGFR is increased 30 days after birth. SORCS2 and NGFR are no longer coexpressed in hippocampus neurons in 60 day old adults (PubMed:29909994). {ECO:0000269|PubMed:11165493, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:29909994}.
Protein families：VPS10-related sortilin family, SORCS subfamily