ZFP57_MOUSE Q8C6P8
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UniProt:Q8C6P8
Recommended name：Zinc finger protein 57
EC number：
Alternative names：(Zfp-57)
Cleaved into：
GeneID：22715
Gene names (primary )：Zfp57
Gene names (synonym )：
Gene names (ORF )：
Length：421
Mass：47959
Sequence：MAARKQSSQPSRTPVSYEDVAVSFTQEEWEYLTSTQKTLYQKVMSETFKNLTFVGSKKKPQEPSSDLQDKNEEQEKSSSCTGVFKGGPFFFCLTCGKCFKKNTFLFNHQFPVRSRRLAVTNPQSRKGKGYKAQHRGERPFFCNFCGKTYRDASGLSRHRRAHLGYRPRSCPECGKCFRDQSEVNRHLKVHQNKPAASNQAGNQASNQRLKSRVPPTTPRSQAPALKYVKVIQGPVARAKARNSGASTLNVRSNSITVVRSREKISCPYCHITFTMRTCLLTHLKIHFRRQPNQHFCCKESAHSSNTLRMQKIYTCPVCDSSFRGKESLLDHLCCQRPIRFSKCWEILGHLLGYLHEPVVLGNIFKVRDSSGKRMESRRRRRKRACTENPETEGLSGKGRVAPWEMEGATSPESPVTEEDSD
Tissue specificity：Expressed in oocytes and in a subset of adult tissues. Expressed at high levels in testis, and at low levels in cerebellum. Present in sciatic nerve and spinal cord (at protein level). {ECO:0000269|PubMed:15070898, ECO:0000269|PubMed:8120052}.
Induction：Up-regulated by LIF. Down-regulated during differentiation of embryonic stem cells, or during retinoic acid-induced differentiation of F9 cells (at protein level). Regulated by JMJD1A, which mediates histone H3K9Me2 demethylation at its promoter, thereby activating expression. {ECO:0000269|PubMed:14732407, ECO:0000269|PubMed:15070898, ECO:0000269|PubMed:15845352, ECO:0000269|PubMed:17938240, ECO:0000269|PubMed:8120052}.
Developmental stage：Expression peaks between 11 dpc and 17 dpc, and decreases from P0 to P28. Expressed in lung throughout embryonic development. At 12 dpc, expressed in spinal cord, dorsal root ganglia and sciatic nerve. At 15 dpc, highly expressed in all neural tissues. At P0, expressed in brain and spinal cord. Present in Schwann cells at 16 dpc and P0 (at protein level). Maternal product is present in preimplantation embryos. Expressed in pluripotent embryonic stem cells. Down-regulated when embryonic stem cells differentiate. {ECO:0000269|PubMed:15070898, ECO:0000269|PubMed:18622393, ECO:0000269|PubMed:18854139, ECO:0000269|PubMed:8120052}.
Protein families：Krueppel C2H2-type zinc-finger protein family