PR15A_MOUSE P17564
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UniProt:P17564
Recommended name：Protein phosphatase 1 regulatory subunit 15A
EC number：
Alternative names：(Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116)
Cleaved into：
GeneID：17872
Gene names (primary )：Ppp1r15a
Gene names (synonym )：Gadd34 Myd116
Gene names (ORF )：
Length：657
Mass：71840
Sequence：MAPSPRPQHVLHWRDAHNFYLLSPLMGLLSRAWSRLRGPEVPEAWLAKTVTGADQIEAAALLTPTPVSGNLLPHGETEESGSPEQSQAAQRLCLVEAESSPPETWGLSNVDEYNAKPGQDDLREKEMERTAGKATLQPAGLQGADKRLGEVVAREEGVAEPAYPTSQLEGGPAENEEDGETVKTYQASAASIAPGYKPSTPVPFLGEAEHQATEEKGTENKADPSNSPSSGSHSRAWEYYSREKPKQEGEAKVEAHRAGQGHPCRNAEAEEGGPETTFVCTGNAFLKAWVYRPGEDTEEEDNSDSDSAEEDTAQTGATPHTSAFLKAWVYRPGEDTEEEDSDSDSAEEDTAQTGATPHTSAFLKAWVYRPGEDTEEENSDLDSAEEDTAQTGATPHTSAFLKAWVYRPGEDTEEENSDLDSAEEDTAQTGATPHTSPFLKAWVYRPGEDTEDDTEEEEDSENVAPGDSETADSSQSPCLQPQRCLPGEKTKGRGEEPPLFQVAFYLPGEKPESPWAAPKLPLRLQRRLRLFKAPTRDQDPEIPLKARKVHFAEKVTVHFLAVWAGPAQAARRGPWEQFARDRSRFARRIAQAEEKLGPYLTPDSRARAWARLRNPSLPQSEPRSSSEATPLTQDVTTPSPLPSETPSPSLYLGGRRG
Tissue specificity：Expressed strongly in spleen and lung, moderately in thymus and muscle, and weakly in brain. {ECO:0000269|PubMed:12824288}.
Induction：Specifically produced in response to stress: in absence of stress, some upstream open reading frame (uORF) of this transcript is translated, thereby preventing its translation (PubMed:19131336). By IL6 and various endoplasmic stresses such as methyl methanesulfonate (PubMed:12606582, PubMed:12824288, PubMed:8139541). {ECO:0000269|PubMed:12606582, ECO:0000269|PubMed:12824288, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:8139541}.; (Microbial infection) By infection with various viruses such as vesicular stomatitis virus (VSV). {ECO:0000269|PubMed:17670836}.
Developmental stage：Expression starts at 8.5 dpc, and decreases to undetectable levels at 10.5 dpc and 11.5 dpc. Expression is strongly up-regulated at 12.5 dpc, decreases at 16.5 dpc and reappears at 18.5 dpc. At 12.5 dpc, ubiquitously expressed, with high levels in brain, spinal cord, tongue, lung and genital tubercle. {ECO:0000269|PubMed:12824288}.
Protein families：PPP1R15 family