SOSD1_MOUSE Q9CQN4
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UniProt:Q9CQN4
Recommended name：Sclerostin domain-containing protein 1
EC number：
Alternative names：(Ectodermal BMP inhibitor) (Ectodin) (Sclerostin-like protein) (Uterine sensitization-associated gene 1 protein) (USAG-1)
Cleaved into：
GeneID：66042
Gene names (primary )：Sostdc1
Gene names (synonym )：Sostl Usag1
Gene names (ORF )：
Length：206
Mass：23174
Sequence：MLPPAIHLSLIPLLCILMRNCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHFSSTGLDRNSRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESVSPAKPAQHHRERKRASKSSKHSLS
Tissue specificity：Highly expressed in kidney at renal collecting ducts level and weakly in brain. {ECO:0000269|PubMed:14623234, ECO:0000269|PubMed:15020244}.
Induction：Up-regulated by BMP2 and BMP7. Down-regulated by FGF4 and SHH. {ECO:0000269|PubMed:14623234}.
Developmental stage：Expression was first detected at 11 dpc throughout the surface of the embryo, and it was most intense in the head region on the surfaces of the mandibular, maxillary, and frontonasal processes. At 11.5 dpc expression is detected in the first and second branchial arches, pharynx and metanephros. At 12 dpc-14 dpc, expression was intense and strikingly confined to developing ectodermal organs. The vibrissae, tylotrich hair follicles, tongue papillae, and tooth germs as well as the ear auricle. Also expressed intensely in kidney epithelium in the stalk and tips of ureter as well as in the spermatic ducts in the testis. At 17.5 dpc strong expression was restricted to kidney tubules and ameloblasts in teeth, and moderate expression was observed in hair follicles, choroids plexus of the fourth cerebral ventricle of the brain. First detected on 12.5 dpc in interstitial cell of the testis and increased towards 14.5 dpc. On 8 dpp (day post partum) highly expression was detected in kidney and weakly in skin. {ECO:0000269|PubMed:12617826, ECO:0000269|PubMed:14623234, ECO:0000269|PubMed:15020244}.
Protein families：Sclerostin family