HTRA1_MOUSE Q9R118
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:Q9R118
Recommended name：Serine protease HTRA1
EC number：EC 3.4.21.-
Alternative names：(High-temperature requirement A serine peptidase 1) (Serine protease 11)
Cleaved into：
GeneID：56213
Gene names (primary )：Htra1
Gene names (synonym )：Htra Prss11
Gene names (ORF )：
Length：480
Mass：51214
Sequence：MQSLRTTLLSLLLLLLAAPSLALPSGTGRSAPAATVCPEHCDPTRCAPPPTDCEGGRVRDACGCCEVCGALEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDAKTYTNLCQLRAASRRSEKLRQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAVTKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVTANDVSDVIKKENTLNMVVRRGNEDIVITVIPEEIDP
Tissue specificity：In the brain, mainly expressed in cortical areas both in glial cells and neurons (at protein level). In bones, deposited in the matrix, with higher level in newly formed bone compared to fully calcified bone (at protein level). Also expressed in the tendons (at protein level). In the articular cartilage, detected only in the deepest zone of the joint cartilage. Not detected in the chondrocytes of the growth plate (at protein level). In an experimental arthritis model, at early disease stages, up-regulated in articular chondrocytes in the deep layers of the cartilage (at protein level). As arthritis progresses, chondrocyte expression expands toward the surface. {ECO:0000269|PubMed:14973287, ECO:0000269|PubMed:15993670, ECO:0000269|PubMed:18551132}.
Induction：
Developmental stage：First detected at 10.5 dpc. At 11.5 dpc, in the developing heart, expressed in the atrioventricular endocardial cushion and the outflow tract (at protein level). At 14.5 dpc, strong expression in the outflow tracts, including valves. In the developing skeleton, expressed at 12.5 dpc in the vertebral column and limbs. At 14.5 dpc, expressed in rudiments of tendons and ligaments along the vertebrae, as well as in mesenchymal cells surrounding precartilage condensations. Not detected in precartilage condensations, nor in chondrocytes, but strongly expressed in ossification centers. At 17.5 dpc, in the hind limb, significant expression persists in tendons and ligaments, but expression in the forming joints is reduced. At this stage, weakly detected in the thin layer of articular surfaces. Postnatally, in long bones, expressed by terminally differentiated hypertrophic chondrocytes that are committed to degeneration and eventually replaced by bone, as well as by osteoblasts at late differentiation stages and by mature osteocytes. In the developing brain, expressed in specific regions of the neuroepithelium in the forebrain and hindbrain adjacent to the forming choroid plexus. From 17.5 dpc till birth, expressed in neurogenic areas including ventricular zones (at protein level). At 12.5 and 14.5 dpc, expressed in Muellerian duct cells and in the surrounding mesenchyme in both male and female gonads. In the lung, detected in the mesenchymal cells. Expressed at 12.5 dpc in abdominal skin, both in epidermis and dermis. Also expressed in the epithelium of developing whiskers at 14.5 dpc. At later stages, localized in the basal layer of epidermis and in the invading epidermal cells that formed the whisker rudiments (at protein level). 9 days after birth, detected in the whisker outer root sheet (at protein level). {ECO:0000269|PubMed:14973287, ECO:0000269|PubMed:15993670, ECO:0000269|PubMed:18551132}.
Protein families：Peptidase S1C family