PLD4_MOUSE Q8BG07
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UniProt:Q8BG07
Recommended name：5'-3' exonuclease PLD4
EC number：EC 3.1.16.1
Alternative names：(Choline phosphatase 4) (Phosphatidylcholine-hydrolyzing phospholipase D4) (Phospholipase D4) (PLD 4)
Cleaved into：
GeneID：104759
Gene names (primary )：Pld4
Gene names (synonym )：
Gene names (ORF )：
Length：503
Mass：56154
Sequence：MDKKKEHPEMRIPLQTAVEVSDWPCSTSHDPHSGLGMVLGMLAVLGLSSVTLILFLWQGATSFTSHRMFPEEVPSWSWETLKGDAEQQNNSCQLILVESIPEDLPFAAGSPTAQPLAQAWLQLLDTARESVHIASYYWSLTGLDIGVNDSSSRQGEALLQKFQQLLLRNISVVVATHSPTLAKTSTDLQVLAAHGAQIRQVPMKQLTGGVLHSKFWVVDGRHIYVGSANMDWRSLTQVKELGAIIYNCSNLAQDLEKTFQTYWVLGTPQAVLPKTWPRNFSSHINRFHPLRGPFDGVPTTAYFSASPPSLCPHGRTRDLDAVLGVMEGARQFIYVSVMEYFPTTRFTHHARYWPVLDNALRAAALNKGVHVRLLVSCWFNTDPTMFAYLRSLQAFSNPSAGISVDVKVFIVPVGNHSNIPFSRVNHSKFMVTDKTAYVGTSNWSEDYFSHTAGVGLIVSQKTPRAQPGATTVQEQLRQLFERDWSSHYAMDLDRQVPSQDCVW
Tissue specificity：Enriched in the white matter of early postnatal brains, as well as in splenic marginal zone cells (PubMed:21085684). Highly expressed in dendritic cells (DCs) and other myeloid cells, with lower expression in B cell (PubMed:30111894). {ECO:0000269|PubMed:21085684, ECO:0000269|PubMed:30111894}.
Induction：Up-regulated by lipopolysaccharide (LPS) stimulation in microglia (PubMed:22102906). Increased expression in activated microglia and in the demyelinating lesions of adult brain (PubMed:22102906). {ECO:0000269|PubMed:22102906}.
Developmental stage：First detected in cerebellum at postnatal day 0 (P0), increased with age and peaked at P7, and then rapidly decreased to adult levels by P21. {ECO:0000269|PubMed:21085684}.
Protein families：Phospholipase D family