TGFI1_MOUSE Q62219
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UniProt:Q62219
Recommended name：Transforming growth factor beta-1-induced transcript 1 protein
EC number：
Alternative names：(Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) (TGF beta-stimulated clone 5) (TSC-5)
Cleaved into：
GeneID：21804
Gene names (primary )：Tgfb1i1
Gene names (synonym )：Ara55
Gene names (ORF )：
Length：461
Mass：50101
Sequence：MEDLDALLSDLETTTSHMSRLGAPKERPPETLTPPPPYGHQPQTGSGESSGTTGDKDHLYSTVCKPRSPKPVAPVAPPFSSSSGVLGNGLCELDRLLQELNATQFNITDEIMSQFPSSKMAEGEEKEDQSEDKSSPTVPPSPFPAPSKPSATSATQELDRLMASLSDFRVQNHLPASGPPQPPAASPTREGCPSPPGQTSKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFLCSGCSTTLGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGEEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECLAPFSGGSFFEHEGRPLCENHFHAQRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERASKPYCQPCFLKLFG
Tissue specificity：Ubiquitously expressed. Higher expression is detected in lung and spleen. Expression decreases during pregnancy in mammary glands. Expressed in all brain areas, with higher levels in cerebellum, prefrontal cortex and hypothalamus. Expressed in smooth muscle, myoepithelial cells and platelets (at protein level). Preferentially expressed in mesenchymal versus epithelial cells (at protein level). {ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:15713747, ECO:0000269|PubMed:16219310, ECO:0000269|PubMed:16219691, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:7929412}.
Induction：Up-regulated during epithelial to mesenchymal transformation. Up-regulated by TGFB1 and hydrogen peroxide. {ECO:0000269|PubMed:16219691, ECO:0000269|PubMed:7929412}.
Developmental stage：First detected in the developing heart tube at 8.0 dpc and then in cardiac, skeletal and smooth muscle during early stages of development. Highly expressed in differentiating gut epithelial cells. {ECO:0000269|PubMed:11437454, ECO:0000269|PubMed:11937715, ECO:0000269|PubMed:15687259}.
Protein families：Paxillin family