SIX2_MOUSE Q62232
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UniProt:Q62232
Recommended name：Homeobox protein SIX2
EC number：
Alternative names：(Sine oculis homeobox homolog 2)
Cleaved into：
GeneID：20472
Gene names (primary )：Six2
Gene names (synonym )：
Gene names (ORF )：
Length：296
Mass：32718
Sequence：MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENSENSNSSSHNPLASSLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHSLQDSILNPMSANLVDLGS
Tissue specificity：Expressed in phalangeal tendons, in smooth muscle and in head and body mesenchyme.
Induction：Down-regulated by CTNNB1 upon differentiarion. Activated by TLX1 in the kidney and repressed by HOXA2 in the branchial arch and facial mesenchyme. {ECO:0000269|PubMed:18321982, ECO:0000269|PubMed:19716816, ECO:0000269|PubMed:22902740}.
Developmental stage：First expressed at 8.5 dpc of embryo development in a restricted mesodermal subpopulation at the anterior hindbrain level. Expression of SIX2 in the developing limb begins at 11 dpc and is more pronounced ventrally. It progresses into the developing phalanges at 12.5 dpc. At 10.5 dpc expressed in the metanephric blastema, which signals the ureteric bud to evaginate from the Wolffian duct. At 11.5 dpc expressed at high levels in the dorsal anephric mesenchyme and is down-regulated where pretubular aggregates will form on the ventral side of the ureteric bud. At 14.5 dpc, expression persists in the peripheral mesenchyme of the renal cortex. At 9.5 dpc, expressed in the splanchnic mesoderm of the stomach anlage. By 10.5 dpc, expressed in the mesoderm of the posterior stomach. Expression is seen in the presumptive glandular stomach primordium at 11.5 dpc. At 12.5 dpc, becomes restricted to the mesenchyme of the antral region of the posterior stomach. At 14.5 dpc, expression remains in the antrum, just anterior to the pyloric sphincter. {ECO:0000269|PubMed:17036046, ECO:0000269|PubMed:19660448}.
Protein families：SIX/Sine oculis homeobox family