M1AP_MOUSE Q9Z0E1
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UniProt:Q9Z0E1
Recommended name:Meiosis 1 arrest protein
EC number:
Alternative names:(Meiosis 1-arresting protein) (Meiosis 1-associated protein) (Spermatogenesis-associated protein 37)
Cleaved into:
GeneID:110958
Gene names (primary ):M1ap
Gene names (synonym ):D6Mm5e Spata37
Gene names (ORF ):
Length:529
Mass:58618
Sequence:MNRRKTTSRGTSAAMKISHQPPRLLIVNIAVPSWVDICPNLCEALQNFFSIACSLMGPSRMSLFSLYTVQNQHECVLPFVQVRGNFIRLQACISELRMLQVEGCHRPPHALLPLAIEDGLQQFKQYSSHMASSAAQPWTSLEITVLTSRPGKEVVKELEEGLKDINLLSVRRLQVAEVTKGIQERSDSPSPTEEPSNDESSILEADIVLETLDNDVVSMEVFFKAWLHNSETDQENIHLLLTPQSLPPPSRAKDHPICLKCDLQERFLSPSLLPGTADGVSRIDDPKGDISTLYQMASLASASPYKLQVVKALKSSGICESLTYGLPFILRPTSCWQLDWDELETNQQHFHALCHCLLKRDWLLLARGEPLIHKHNQSLPACSFYVITPSHSLTLLVKLVATRELMLPGFFPLLSEDPPEDSLKIIESTLDSLDLGLTYNPLHVGSHLYSHLSSAHAKPQGRLYTSCASRGLRKGGQLQTNRVRAAVVPLPVAPAPRRALKMTAASKASSAAFLPSDSEEGEEERPSHT
Tissue specificity:Expressed in germ cells of the testis. Expressed from spermatogonia to spermatids. Expressed at very low levels in lung, stomach, thymus. Not detected in Sertoli cells. {ECO:0000269|PubMed:16881047, ECO:0000269|PubMed:23269666, ECO:0000269|PubMed:9927484}.
Induction:
Developmental stage:Germ cell-specific, but may also be expressed in cells that require the presence of germ cells. Cranial to caudal punctate expression is seen in the developing ovary starting at 13.5 dpc. At 13.5 dpc. expressed in the cranial part of the XX gonad. At 14.5 dpc, expression extends to almost two-thirds of the XX gonad, and by 15.5 dpc expression is seen throughout the entire organ. By 16.5 dpc, expression is only detected in the most caudal tip of the XX gonad. Expression switches from the embryonic ovary to the postnatal testis. {ECO:0000269|PubMed:16881047, ECO:0000269|PubMed:23269666}.
Protein families: