CPEB4_MOUSE Q7TN98
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UniProt:Q7TN98
Recommended name：Cytoplasmic polyadenylation element-binding protein 4
EC number：
Alternative names：(CPE-BP4) (CPE-binding protein 4) (mCPEB-4)
Cleaved into：
GeneID：67579
Gene names (primary )：Cpeb4
Gene names (synonym )：Kiaa1673
Gene names (ORF )：
Length：729
Mass：80122
Sequence：MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPNPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKAEENPGDSSSENSNGKEKLRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPGASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRSAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGASQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPERPRTFDMHSLESSLIDIMRAENDSIKGRLNYSYPGSDSSLLINARTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFTHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN
Tissue specificity：Highly expressed in brain, including hippocampus, amygdala, granule and Purkinje cells of the cerebellum (at protein level) (PubMed:17024188, PubMed:24386439). Expressed in spinal cord (at protein level) (PubMed:27381259). Expressed in kidney, lung and heart (at protein level) (PubMed:12871996, PubMed:27381259, PubMed:24386439). Expressed in liver (at protein level) (PubMed:28092655, PubMed:12871996, PubMed:27381259, PubMed:24386439). Expressed in spleen and testis (at protein level) (PubMed:24386439, PubMed:12871996). Weakly expressed in ovary and in granular cells of dentate gyrus and the pyramidal cells of CA3 and CA1 of the hippocampus (PubMed:12871996). {ECO:0000269|PubMed:12871996, ECO:0000269|PubMed:17024188, ECO:0000269|PubMed:24386439, ECO:0000269|PubMed:27381259, ECO:0000269|PubMed:28092655}.
Induction：Up-regulated in granular cells of the dentate gyrus of CA1 and CA3 after kainate-induced seizures (PubMed:12871996). Up-regulated by high-fat-diet and aging-induced endoplasmic reticulum stress (PubMed:28092655). Expression level fluctuation follows the circadian clock amplitude (PubMed:28092655). {ECO:0000269|PubMed:12871996, ECO:0000269|PubMed:28092655}.
Developmental stage：Highly expressed in developing brain, spinal cord and attached dorsal root ganglia (DRG) (at protein level). At embryonic day 18.5 expressed in gray matter of spinal cord, diencephalons, hippocampus and parts of midbrain and hindbrain. At postnatal day 20 expression persists in spinal cord and brain. Expressed in embryonic heart. {ECO:0000269|PubMed:27381259}.
Protein families：RRM CPEB family