NEIL3_MOUSE Q8K203
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UniProt:Q8K203
Recommended name：Endonuclease 8-like 3
EC number：EC 3.2.2.-
Alternative names：(DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3)
Cleaved into：
GeneID：234258
Gene names (primary )：Neil3
Gene names (synonym )：
Gene names (ORF )：
Length：606
Mass：67416
Sequence：MVEGPGCTLNGEKIRARVLPGQAVTGVRGTALQSLLGPAMSPAASLADVATSAAPMNAKDSGWKLLRLFNGYVYSGVETLGKELFMYFGPRALRIHFGMKGSILINPREGENRAGASPALAVQLTRDLICFYDSSVELRNSVESQQRVRVMEELDICSPKFSFSRAESEVKKQGDRMLCDVLLDQRVLPGVGNIIKNEALFDSGLHPAVKVCQLSDKQACHLVKMTRDFSILFYRCCKAGSAISKHCKVYKRPNCDQCHSKITVCRFGENSRMTYFCPHCQKENPQCVQVCQLPTRNTEISWTPRGEDCFTDSVARKSEEQWSCVVCTLINRPSAKACDACLTTRPLDSVLKNRENSIAFNNLVKYPCNNFENTHTEVKINRKTAFGNTTLVLTDLSNKSSALARKKRANHTIDGESQMFLPTDIGFSDSQHPSKEGINYITQPSNKVNISPTVCAQSKLFSSAHKKFKPAHTSATELKSYNSGLSNSELQTNRTRGHHSKSDGSPLCKMHHRRCVLRVVRKDGENKGRQFYACSLPRGAQCGFFEWADLSFPFCRHGKRSIMKTVLKIGPNNGKNFFVCPLEKKKQCNFFQWAENGPGMEIVPGC
Tissue specificity：Expressed in testis, thymus, spleen and bone marrow. In young mice, expressed at higher levels in thymocytes than splenocytes. At 12 dpc, abundant in the subventricular zone (SVZ) of the lateral ventricles. At 17.5 dpc and P0, expression is limited to distinct cells in the cortical SVZ, in cells of the secondary matrix, the dentate gyrus migratory route and the dentate gyrus. {ECO:0000269|PubMed:16428305, ECO:0000269|PubMed:19170771, ECO:0000269|PubMed:19426544, ECO:0000269|PubMed:23305905}.
Induction：By mitogen stimulation in splenocytes, and by hypoxic-ischemic injury in the striatum and hippocampus. {ECO:0000269|PubMed:16428305, ECO:0000269|PubMed:22065741}.
Developmental stage：Highly expressed in the developing brain at 12 dpc-13 dpc when neurogenesis starts. Expression decreases during later development and is undetectable in adult brain. {ECO:0000269|PubMed:19170771, ECO:0000269|PubMed:19426544}.
Protein families：FPG family