SPTC2_MOUSE P97363
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UniProt:P97363
Recommended name：Serine palmitoyltransferase 2
EC number：EC 2.3.1.50
Alternative names：(Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)
Cleaved into：
GeneID：20773
Gene names (primary )：Sptlc2
Gene names (synonym )：Lcb2
Gene names (ORF )：
Length：560
Mass：62982
Sequence：MRPEPGGCCCRRPMRANGCVKNGEVRNGYLRSSTATVAAAGQIHHVTENGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRHWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGAKVDIMERKSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAEVLKEYGAGVCSTRQEIGNLDKHEELEKLVARFLGVEAAMTYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPSGRGVVDYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSMSPPVMEQIITSMKCIMGQDGTSLGKECIQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED
Tissue specificity：Expressed in a variety of tissues. Expressed in brains cortices (at protein level) (PubMed:21994399). Expressed in brown and white adipose tissues (PubMed:28698261, PubMed:27818258). Expressed in liver (PubMed:27818258). {ECO:0000269|PubMed:21994399, ECO:0000269|PubMed:27818258, ECO:0000269|PubMed:28698261}.
Induction：Expression levels increase upon high-fat diet (at protein level). {ECO:0000269|PubMed:21994399, ECO:0000269|PubMed:28698261}.
Developmental stage：In brains, expressed at low levels after birth, expression highly increases at 2 weeks after birth to decrease and be maintained at 4 weeks after birth until, at least, 18 months (PubMed:21994399). Expression increases in differentiated adipocytes (PubMed:28698261). {ECO:0000269|PubMed:21994399, ECO:0000269|PubMed:28698261}.
Protein families：Class-II pyridoxal-phosphate-dependent aminotransferase family