RORA_MOUSE P51448
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UniProt:P51448
Recommended name：Nuclear receptor ROR-alpha
EC number：
Alternative names：(Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha)
Cleaved into：
GeneID：19883
Gene names (primary )：Rora
Gene names (synonym )：Nr1f1 Rzra
Gene names (ORF )：
Length：523
Mass：58845
Sequence：MESAPAAPDPAASEPGSSGSEAAAGSRETPLTQDTGRKSEAPGAGRRQSYASSSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSTYMDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
Tissue specificity：Expressed in cerebellum, heart, liver, lung, kidney, retina and brown and white adipose tissues. Expressed in the subset of mature Th17 cells. {ECO:0000269|PubMed:17666523, ECO:0000269|PubMed:18164222, ECO:0000269|PubMed:18441015, ECO:0000269|PubMed:22753030}.
Induction：In T(H) cells, induced upon antigen receptor ligation in the presence of IL6 and TGB1 (via STAT3). Oscillates diurnally in central nervous system. In liver, Isoform 1 oscillates diurnally but not isoform 4. {ECO:0000269|PubMed:18164222, ECO:0000269|PubMed:21499262, ECO:0000269|PubMed:22753030, ECO:0000269|PubMed:23172836}.
Developmental stage：In cerebellum, expression begins at 12.5 dpc. In the developing retina, first expressed at 17 dpc in the ganglion cell layer. At P3, expressed in the inner border of the neuroblasitic border (presumptive amacrine cells). By P6, levels increase in developing cones. Expression found in the presumptive bipolar cells by P9. During adipocyte differentiation, expression gradually increases. {ECO:0000269|PubMed:14687547, ECO:0000269|PubMed:19014374, ECO:0000269|PubMed:19324970}.
Protein families：Nuclear hormone receptor family, NR1 subfamily