SOLH1_MOUSE Q6IUP1
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UniProt:Q6IUP1
Recommended name：Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1
EC number：
Alternative names：
Cleaved into：
GeneID：227631
Gene names (primary )：Sohlh1
Gene names (synonym )：Gm110 Tohlh1
Gene names (ORF )：
Length：357
Mass：38188
Sequence：MASGGHERANEDYRVSGITGCSKTPQPETQDSLQTSSQSSALCTAPVAAANLGPSLRRNVVSERERRRRISLSCEHLRALLPQFDGRREDMASVLEMSVYFLQLAHSMDPSWEQLSVPQPPQEMWHMWQGDVLQVTLANQIADSKPDSGIAKPSAVSRVQDPPCFGMLDTDQSQATERESELLERPSSCPGHRQSALSFSEPESSSLGPGLPPWIPHSWQPATPEASDIVPGGSHQVASLAGDPESSGMLAEEANLVLASVPDARYTTGAGSDVVDGAPFLMTTNPDWWLGSVEGRGGPALARSSPVDGAEPSFIGDPELCSQELQAGPGELWGLDFGSPGLALKDEADSIFPDFFP
Tissue specificity：In males, it is mainly expressed in testis, while in females it is mainly expressed in ovary. In testis, it is exclusively expressed in spermatogonia, with a preference for prespermatogonia and type A spermatogonia. In ovary, it is detected in germ cell cysts, primordial follicles, and primary follicles but is undetectable by the secondary follicle stage (at protein level). Expressed in the majority of spermatogonia in adult animals, but not in the most undifferentiated spermatogonial population (PubMed:22056784). {ECO:0000269|PubMed:16564520, ECO:0000269|PubMed:16690745, ECO:0000269|PubMed:22056784}.
Induction：Transcription is activated by DMRT1 in undifferentiated spermatogonia. {ECO:0000269|PubMed:20951351}.
Developmental stage：In male testis, it is expressed as early as 12.5 dpc. After birth, it localizes to type A spermatogonia in 7-day-old testis and adult testis, but not in spermatocytes. In spermatogonia, it is initially detected in stage IV Aal spermatogonia and strongly expressed in Aal, A1, A2, A3, A4, intermediate and type B spermatogonia (at protein level). In ovary, it is detected at 15.5 dpc, when oocytes have entered meiosis I, although a low level expression is detectable at 13.5 dpc. Expressed in oocytes of germ cell cysts as well as primordial follicles in the newborn ovary. In adult ovaries, it is preferentially expressed in primordial oocytes but disappear rapidly as the oocytes are recruited to form primary and secondary (multilayer and preantral) follicles. During oocyte differentiation, protein appearance at 15.5 dpc correlates with SOHLH2 translocation from the cytoplasm into the nucleus and is dependent on SOHLH2 expression (PubMed:28504655). {ECO:0000269|PubMed:16564520, ECO:0000269|PubMed:16690745, ECO:0000269|PubMed:28504655}.
Protein families：