SYNE4_MOUSE Q8CII8
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:Q8CII8
Recommended name：Nesprin-4
EC number：
Alternative names：(KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4)
Cleaved into：
GeneID：233066
Gene names (primary )：Syne4
Gene names (synonym )：
Gene names (ORF )：
Length：388
Mass：42024
Sequence：MALVPPLGREFPPEPVNCPLAAPRELDVVGGTICPAPEEETSRPEQVQASLGLPEHCMGELKSTESATSPSRLPLASSHEHQDGGKPCEHSDSGLEVLEAEQDSLHLCLLRLNFRLQDLERGLGSWTLAHNRIVQMQALQAELRGAAERVDALLAFGEGLAERSEPRAWASLEQVLRALGTHRDTIFQRLWQLQAQLISYSLVLEKANLLDQDLEVEGDSDGPAAGGVWGPWAPSTFPTPAELEWDPAGDVGGLGPSGQKISRIPGAPCELCGYRGPQSSGQGLEDLLSLGLGHRKHLAAHHRRRLRKPQDRKRQVSPSLPDAMLEVDRGVPAPASKRPLTLFFLLLFLLLVGATLLLPLSGVSCCSHARLARTPYLVLSYVNGLPPI
Tissue specificity：Expressed in secretory epithelial cells, such as those found in exocrine pancreas, bulbourethral gland, mammary gland and salivary gland (at protein level). Also expressed in the cochlea, where it is restricted primarily to the 3 rows of outer hair cells and 1 row of inner hair cells (at protein level). Not detected in other cells of the cochlea, including Deiter's cells and pillar cells, nor in liver and kidney (at protein level). {ECO:0000269|PubMed:19164528, ECO:0000269|PubMed:23348741}.
Induction：
Developmental stage：In the cochlea, low expression at P0 and P15, then rises significantly by P30 and remains steady. In the HC11 cell line model, up-regulated during differentiation of mammary cells into milk-secreting cells (at protein level). {ECO:0000269|PubMed:19164528}.
Protein families：Nesprin family