CBLN1_MOUSE Q9R171
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UniProt:Q9R171
Recommended name：Cerebellin-1
EC number：
Alternative names：(Brain protein D3) (Precerebellin)
Cleaved into：Cerebellin (CER); [des-Ser1-cerebellin (des-Ser1-cerebellin)
GeneID：12404
Gene names (primary )：Cbln1
Gene names (synonym )：
Gene names (ORF )：
Length：193
Mass：21113
Sequence：MLGVVELLLLGTAWLAGPARGQNETEPIVLEGKCLVVCDSNPTSDPTGTALGISVRSGSAKVAFSAIRSTNHEPSEMSNRTMIIYFDQVLVNIGNNFDSERSTFIAPRKGIYSFNFHVVKVYNRQTIQVSLMLNGWPVISAFAGDQDVTREAASNGVLIQMEKGDRAYLKLERGNLMGGWKYSTFSGFLVFPL
Tissue specificity：Expressed and secreted by presynaptic neurons, such as cerebellar granule cells. Following secretion, the protein binds to GRID2 on the postsynaptic Purkinje cell membranes. Expressed at the highest level in the cerebellar cortex. High levels are also seen in the olfactory bulb, posterior part of the cerebral cortex, certain thalamic nuclei, and deep cerebellar nuclei. Low to moderate levels are detected in some hypothalamic and brainstem nuclei. In the thalamus, expressed in parafascicular nucleus neurons and other regions (at protein level). {ECO:0000269|PubMed:16930405, ECO:0000269|PubMed:17030622, ECO:0000269|PubMed:22220752, ECO:0000269|PubMed:23141067, ECO:0000269|PubMed:3199194, ECO:0000269|PubMed:3420533}.
Induction：
Developmental stage：In the developing brain, expressed as early as embryonic day 10-13, and transiently up-regulated during the late embryonic and neonatal periods. Cerebellin and [des-Ser1]-cerebellin are expressed as easly as postnatal day 3-4. The levels of both peptides rise rapidly to a maximum at approximately day 25-30 after birth, whereafter they fall to stable adult values. {ECO:0000269|PubMed:16930405, ECO:0000269|PubMed:3199194}.
Protein families：