TOX_MOUSE Q66JW3
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UniProt:Q66JW3
Recommended name：Thymocyte selection-associated high mobility group box protein TOX
EC number：
Alternative names：(Thymus high mobility group box protein TOX)
Cleaved into：
GeneID：252838
Gene names (primary )：Tox
Gene names (synonym )：
Gene names (ORF )：
Length：526
Mass：57203
Sequence：MDVRFYPPPAQPAAAPAAPCLGPSPCLDPYYCNKFDGENMYMSMTEPSQDYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFHPQTMDLPEITVSNMLGQDGALLSNSISVMQEIGNAEGAQYSSHPQMAAMRPRGQPTDIRQQASMMQPGQLTTINQSQLSAQLGLNMGGTNVAHNSPSPPGSKSATPSPSSSVHEDECEDASKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYTDPVDVKTSQPPQLVNSKPSVFHGPSQAHSALYLSSHYHQQPGMTPQLTAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLSMQQHQSLAMQQPLGSQLPMQVQTALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWSTDYCSSGGMQRDKALYLT
Tissue specificity：Expressed in neurons of the subventricular zone (at protein level) (PubMed:25527292). Expressed in distinct subpopulations of thymocytes undergoing positive selection: double CD4-positive CD8-positive (DP) cells, CD4-positive CD8-low transitional cells and in single CD4-positive and CD8-positive cells (at protein level) (PubMed:11850626, PubMed:15078895). Expressed in ILC progenitors and mature ILC subsets: ILC1, ILC2 and ILC3 (at protein level) (PubMed:25915732). Expressed in lymphoid tissue-inducer cells and bone marrow NK cell subsets (PubMed:20818394). Abundant in thymus, liver and brain. Also detected in small intestine, spleen, stomach and testis (PubMed:11850626). Highly expressed in tumor-infiltrating CD8-positive T cells (at protein level) (PubMed:31207604). {ECO:0000269|PubMed:11850626, ECO:0000269|PubMed:15078895, ECO:0000269|PubMed:20818394, ECO:0000269|PubMed:25527292, ECO:0000269|PubMed:25915732, ECO:0000269|PubMed:31207604}.
Induction：Transiently up-regulated during key developmental transition of immune cell subsets, likely marking a developmental checkpoint. Up-regulated during beta and positive selection of developing thymocytes, upon activation of pre-T cell receptor or T cell receptor in a calcineurin-dependent manner (PubMed:11850626, PubMed:15078895). Low expression is detected in precursor bone marrow NK cells, then is up-regulated in immature and mature bone marrow NK cells and later down-regulated in splenic mature NK cells (PubMed:20818394). {ECO:0000269|PubMed:11850626, ECO:0000269|PubMed:15078895, ECO:0000269|PubMed:20818394}.; (Microbial infection) Up-regulated in LCMV-specific CD8-positive T cells. Expressed at high levels in exhausted T cells during chronic infection. {ECO:0000269|PubMed:31207603}.
Developmental stage：In the developing brain, expressed at embryonic day (E) 9.5 in neuroepithelium, displaying a rostral-high/ caudal-low and lateral-high/medial-low expression pattern. Abundant at E15.5 in progenitors of the ventricular zone and differentiated neurons in the cortical plate. The lateral-medial gradient spread further in all cells of the ventricular zone of the lateral cortex by E18.5 (at protein level). {ECO:0000269|PubMed:25527292}.
Protein families：High motility group (HMG) box superfamily