SOCS1_MOUSE O35716
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UniProt:O35716
Recommended name：Suppressor of cytokine signaling 1
EC number：
Alternative names：(SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1)
Cleaved into：
GeneID：12703
Gene names (primary )：Socs1
Gene names (synonym )：Cish1 Ssi1
Gene names (ORF )：
Length：212
Mass：23715
Sequence：MVARNQVAADNAISPAAEPRRRSEPSSSSSSSSPAAPVRPRPCPAVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI
Tissue specificity：High expression in thymus. Lower expression in lung and spleen (PubMed:9202125). Expressed in both Th1 and Th2 cells. {ECO:0000269|PubMed:12242343, ECO:0000269|PubMed:9202125}.
Induction：By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families.
Developmental stage：In the developing brain, expressed at low levels from 10 dpc stages to young adulthood (P25) with peak levels from 14 dpc to P8. In the cortex, expression first observed at 14 dpc uniformly in all cells. Also expressed in the innermost layers of the developing retina. Levels of expression remain unchanged from P8 until adulthood. In the peripheral nervous system, high levels found in virtually all neurons of the dorsal root ganglion.
Protein families：SOCS1 family