PRUN2_MOUSE Q52KR3
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UniProt:Q52KR3
Recommended name：Protein prune homolog 2
EC number：
Alternative names：(BNIP2 motif-containing molecule at the C-terminal region 1)
Cleaved into：
GeneID：353211
Gene names (primary )：Prune2
Gene names (synonym )：Bmcc1 Kiaa0367
Gene names (ORF )：
Length：3084
Mass：339516
Sequence：MEEFLQRAKSKLDRSKQLEQVHAVIGPKSCDLDSLISAFTYAYFLDKVSPPGVLCLPVLNIPRTEFNYFTETRFILEELNIPESFHIFRDEINLHQLNDEGKLSITLVGSHVLGSEDRTLESAVVRVINPGEQSDGELGFPETSSSLVLKELLREAPELITQQLAHLLRGSILFTWMSMDPELPEKQEEILSILEEQFPNLPPRDDIINVLQESQLSAQGLSLEQTMLKDLKELSDGEIKVAISTVNMTLEDYLLHGNITSDLKAFTDKFGFDVLILISSFTWEEQQRQQIAVYSQNLELCSQICCELEESQNPCLELEPFECGCDEILVYQQEDPSVTSDQVFLLLKEVINRRCAEMVSNSRTSSTEAVAGSAPLSQGSSGIMELYGSDIEPQPSSVNFIENPPELNDSNQAQADGNIDLVSPDSGLATIRSSRSSKESSVFLSDDSPVGDGGAPHHSLLPGFDSYSPIPEGIVAEEHAHSGEHSEHFDLFNFDSAPIASEQSQPSSHSADYSPEDDFPNSDSSEGNLSAGPKGLGEMGINMSNYSSSSLLSEAGKDSLVEFDEEFIQRQESSGDNSERNLSLTCFAGEEPSSPERLKNPGKMIPPTPMNSFVEISPSNEEPTPLYPEDIIQNAIDTGHLGPPQARARCRSWWGGLEIDSKNVVDTWNASEQESVFQSPEPWKDPKPEPVERRTSDSTFQPKSLEFSKSDPWESEFGQPELGNKEAQDQKEESLQYQHLPTVRPHLTDASPHGTNHLIEDFAALWHSGHSPTTMPEPWGNPTDAGEAAVTMSFPTWGAFDKEEDNADTLKNTWNLHPTNNETPSGQEPSEWAMGQSGFSFPAADLLDNPLIEVNKDAAPEIWGKNNSSKDTSLTSGSPTSDLGQTWNNSKLPGEDQNGLVDPKATGKVYEKEGSWSLFEESAKKRGADVLAPWEDSFLSYKCSDYSASNIGEDSVPSPLDTNYSTSDSYTSPTYAGDEKEIANKPVDKDNGFEAKDAEFPAEGLEVLATSSQQSQRNRIGSGPGNLDMWALPHTEDKPEGNDAHHPDSDALKTEHAEDKNASMEDDVRESSPSSYDDPSMMRLYEANRQLTLLHSNTNSRQAAPDSLDTWNRVTLEDTQSTATISDMDNDLDWDDCSGGVAISGDGQAEGYIAANSEPETRFSVKQLEPWGTEHQEANQVDWDLSASAEPTGDPGPSEYQTLNEKTGQLIANSIWDSVMGDKNMPSFRLPSPPNTVDMEHGTWPSESPRHSNGKDSHMLEASRLSESGGLTSQPVNQDTWGDSQGDTASSVTGLASPEHFAQSDPWTGHTYGQSESEIEGLVASDCEHLDKEAALGSGVNGAPWAFGKKPRDQEFSSSDAFEHQDISSASGKISSLSVTSSPQSEEPGEALEVEKEPFILDSLAVQTETFTWDLQSKDTHEESLVDHRNLGEANTTLDRINPMKNRPLSGMELEKTEACTILKPERANGKLLYESSQDFGVWDGPMDSDVWDSHISYETAMNSTGQRTEERSLEALSPGNYDRDSLSSGCTHSSASSPDLHDSSVALSSWTYGPSAEHQKENHDDANKQIHQESELFTTEAHVDVITEMKDFVENREDGFGKMSNQEDPQFPEIPNDPFNSGPSSSSSSLGADKYSEYSHAYQEGDLTTKRQEENELGFLEIVEPEGTRIISTSSGSGNDSGGDEELLEKELHLATVAQSEAGACTSLHEPAFSATEHSKPEFSVFVGSLESIEKENKSSPFSDSQQSSPGQWILSPLMQADTQDTCKEETRAAETGTMDTTWHGSASTEAKNGDPDKLEMLGFSADSTEWWNAGAQEGRANAGMSAEELSNSEGELEPTSPVFQNAGPWSLPIQNDSEPVDTGSTNPFRGKLKSPVLDSHGDKSQEKLWNIQPKQLDSDANQLSQLVILDQMKDKDSGQQTAMSPAAGDLPAETLTQGQGRESMLSVWDRAEPALTHRDENGCVSTGVSPTECQQENQWEPEKPYLSHVTHSSTPTENALESNAPTQLMRKLDSDWNSPSPSEPQHNFVPDILHGNFEEGGQLASASPDLWMDVKQPFSFKVDSENPDILTHCDHDSNSQASSSPDVCHDSEGEQKMEKHTAVYLGLEVEPSEFSLTEPNMNDEPTWEPEQESLPHNSELHSEHAMPLPPIDSQNDINNSSKPASSRSSPEPSDMRGDNNTSVTSMEEDTNPEVEAVDSVTIPGHFPRSEDADTFEAHQEVSVEVDDSWVSKDLCPESQTGTRALLDCEQPFASESPAVLTDIFLTSDTCLDVSEAALDHSFSDASGLNTSTGTIDDMSKLTLSEGHPETPVDGDAGKQDVCSSEASWGDFEYDAMGQNIDEELMREPEHFLYGGDLPSEESALKQSLTPYTPPFDLSYLTEPTGCTETAQGAESPGDESLGSDAAEMLLSALPDHREEDKAETNIRKPRYQMTVLHIHEDPEALSSPVGGTGSNNESSPSNIDWEIETDNSDSPAGGDMKPPNGKEILELEEDEKVIPTKGPKQTELEYKEEKQPEQSEDHQVLAVDYILVSHEKDSPLKPEAREARENIPELEQLSIGSRETGLPETQLSGTPDTCQSEFLNDVKVHSAERMSSSSNHESASLENPAQDQSWMVLSHSEVGDPPTETRDSGPESPGRTPEPFLSLSLDKGPKSQVLERNKPLNSLALEEVAGLSSQSRNIERQGQAGLDAVPTQAATHDNEWEMLSPQLSRKNRNPPQEMEEETQCPEPGPRKPRLKGPPSEDEGMDIHFEEGVLSPSAADMRPEPPNSLDLNGSHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTNHEDPTANKSSGQESESIPEYTAEEEREDNRLWRTVVIGEQEQRIDMKVIEPYRRVISHGGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAEDYMIVYLNGATPRRKMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFISSKFSSKIKYVTSLSELSGLIPMDCIHIPESIIKYDEEKSFKRSVRLDEELREASEAAKTSCLYNDPEMSSMEKDIDMKLKEKP
Tissue specificity：
Induction：Down-regulated after nerve growth factor (NGF)-induced differentiation, and up-regulated during the NGF-depletion-induced apoptosis. {ECO:0000269|PubMed:16288218}.
Developmental stage：In the embryo specifically expressed in neural tube and neural crest-related tissues. At 10.5 dpc, highly expressed in neural tube and pharyngeal arches which are derived from neural crest. Expression is more restricted in the later stages of development. At 12.5 dpc, expressed in spinal cord, hindbrain, midbrain, forebrain and dorsal root ganglia (DRG). Although the expression at 14.5 dpc is similar to those in 12.5 dpc, the regions expressing in hindbrain, spinal cord and forebrain at 14.5 dpc are more dorsally restricted than at 12.5 dpc. {ECO:0000269|PubMed:16288218}.
Protein families：PPase class C family, Prune subfamily