GLCNE_MOUSE Q91WG8
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UniProt:Q91WG8
Recommended name：Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
EC number：EC 3.2.1.183
Alternative names：(UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (UDP-GlcNAc-2-epimerase) (Uridine diphosphate-N-acetylglucosamine-2-epimerase); N-acetylmannosamine kinase (ManAc kinase)]
Cleaved into：
GeneID：50798
Gene names (primary )：Gne
Gene names (synonym )：Glcne Uae1
Gene names (ORF )：
Length：722
Mass：79199
Sequence：MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPAFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKCKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERISLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPQEGVVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAAMAERKFGQGKGQENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNVKAQSILRTAGTALGLGVVNILHTMNPSLVILSGVLASHYIHIVKDVIRQQALSSVQDVDVVVSDLVDPALLGAASMVLDYTTRRIH
Tissue specificity：Widely expressed. Highest expression in liver. Also found at high levels in lung, brain and kidney. {ECO:0000269|PubMed:10103025}.
Induction：
Developmental stage：In the embryo, expressed at day 7 dpc, 11 dpc and 15 dpc. {ECO:0000269|PubMed:10103025}.
Protein families：UDP-N-acetylglucosamine 2-epimerase family; ROK (NagC/XylR) family