NKX12_MOUSE P42580
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UniProt:P42580
Recommended name：NK1 transcription factor-related protein 2
EC number：
Alternative names：(Homeobox protein SAX-1) (NKX-1.1)
Cleaved into：
GeneID：20231
Gene names (primary )：Nkx1-2
Gene names (synonym )：Nkx1.1 Sax1
Gene names (ORF )：
Length：305
Mass：32013
Sequence：MLAWQDVGAKAAPSHHKISFSVLDILDPQKFTRAALPPVRLAALEAKKSLEEVEAGQDACSGNPIGSQETPDAVGRGIDPGSPVEGSEAEEEEEAEDAGRAHQPERWQGVHEGSPEARAVAVGTEESGAEGLPASPGSPGSPRPRRRRAESSCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAVQAGGGAPQPGTPGAVAGGGGSATGSSPGPPVPGALPYQTFPTYPATNVLFPAASFPLTTAANGSPFTPFLGPSYLTPFYAPHL
Tissue specificity：Expression detected in adult brain, testis and spleen. In the testis, expressed in the germ cells of the seminiferous epithelium, in elongating spermatids and in spermatozoa. Expressed throughout the brain with highest levels in regions of the cerebral cortex, hippocampus, diencephalon, pons, medulla and cerebellum. In the embryo, expressed in the developing posterior central nervous system. First seen in the ectoderm lateral to the primitive streak, later it encompasses the neural plate. Starting at day 9.5 pc, expressed in distinct areas of spinal cord, hindbrain, midbrain and forebrain. {ECO:0000269|PubMed:10681422, ECO:0000269|PubMed:7669696}.
Induction：
Developmental stage：In the embryo, expressed at highest levels at day 10 with levels decreasing during further development. {ECO:0000269|PubMed:10681422}.
Protein families：NK-1 homeobox family