VANG2_MOUSE Q91ZD4
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UniProt:Q91ZD4
Recommended name：Vang-like protein 2
EC number：
Alternative names：(Loop-tail protein 1) (Loop-tail-associated protein) (Van Gogh-like protein 2)
Cleaved into：
GeneID：93840
Gene names (primary )：Vangl2
Gene names (synonym )：Lpp1 Ltap
Gene names (ORF )：
Length：521
Mass：59771
Sequence：MDTESQYSGYSYKSGHSRSSRKHRDRRDRHRSKSRDGSRGDKSVTIQAPGEPLLDNESTRGDERDDNWGETTTVVTGTSEHSISHDDLTRIAKDMEDSVPLDCSRHLGVAAGAILALLSFLTPLAFLLLPPLLWREELEPCGTACEGLFISVAFKLLILLLGSWALFFRRPKASLPRVFVLRALLMVLVFLLVISYWLFYGVRILDARERSYQGVVQFAVSLVDALLFVHYLAVVLLELRQLQPQFTLKVVRSTDGASRFYNVGHLSIQRVAVWILEKYYHDFPVYNPALLNLPKSVLAKKVSGFKVYSLGEENSTNNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRRARLVVAVEEAFTHIKRLQEEEQKNPREVMDPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGPTIQYHKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLSEEFVDPKSHKFVMRLQSETSV
Tissue specificity：Primarily expressed in the brain and epididymis. Not detected in the cochlea of Lp mice. {ECO:0000269|PubMed:11431695, ECO:0000269|PubMed:11709546, ECO:0000269|PubMed:12724779, ECO:0000269|PubMed:16687519}.
Induction：
Developmental stage：In the embryo, strongly expressed in the neuroectoderm from the earliest stages of neural induction through the late stages of neural tube closure. Detected in the dorso-ventral axis of the neural tube, but not in the floor plate. Expression is low at day 7 dpc; it peaks at 11 dpc, and it remains strong at 15 dpc and 17 dpc. Also expressed in the cochlear epithelium at days 14.5 dpc and 16.5 dpc. Detected at low levels in the outflow tract myocardium from 9.5 dpc with levels increasing by 11.5 dpc. {ECO:0000269|PubMed:11431695, ECO:0000269|PubMed:12724779, ECO:0000269|PubMed:15637299}.
Protein families：Vang family