SOLH2_MOUSE Q9D489
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UniProt:Q9D489
Recommended name：Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
EC number：
Alternative names：
Cleaved into：
GeneID：74434
Gene names (primary )：Sohlh2
Gene names (synonym )：Tohlh2
Gene names (ORF )：
Length：467
Mass：51325
Sequence：MADRISTGELGRRPGQGRVNLLLVGDATRYFLAGSMQKFFPSTAQITLTISNVKKVAVLLAANSFDIIFLKVTSTLTAEEQEAAKLIRSGKKKNTHLLFAFVIPERLKGYVSEYGADISFSEPLTLEKVNTVIHYWKTYFTNTDMENTELPPECRLYFQTSRSELGGRFSTDMFLCSELLKNDARLGLKAPLSSLDKSKQASFLHSTKEKLRRERIKSCCEQLRTLLPYVKGRKSDVASVIEATVDYVKQVRESLSPAIMAQVTEAIQNNRRFSKRQMPIELFLPFSATSQREDAMLTSAFSPVQEIQLLADRGLNVYSMTAAGGALEGAVRGQPGSVSESSIEDLYKTRVPSTARSLNSFHSVKYTSGTVSPHEAAARTNQNISTYLPPTAPSVSNFIPQHCNAMLCPARPTSPNCLCTPGHELAASSRAASASIFRGFRAASASDHQASQPPALPSPQPHDSSYF
Tissue specificity：Preferentially expressed in the adult ovary and testis. Expressed in the majority of spermatogonia in adult animals, but not in the most undifferentiated spermatogonial population (PubMed:22056784). {ECO:0000269|PubMed:22056784}.
Induction：Up-regulated in mice lacking Sohlh1.
Developmental stage：In the embryonic gonads it is expressed as early as 13.5 dpc and later. In 3-day-old postnatal ovaries, it is expressed within oocytes in germ cell clusters and primordial follicles. In the adult, it is expressed only in small follicles, primary primordial and primary follicles. In testis, it is exclusively present in spermatogonia. Present at postnatal day 5, when spermatogonia stem cells differentiate into type A spermatogonia. Absent in Sertoli cells or spermatocytes (at protein level). Expressed in the germline as early as 12.5 dpc and precedes SOHLH1 protein expression, which occurred circa 15.5 dpc. SOHLH1 appearance at 15.5 dpc correlates with SOHLH2 translocation from the cytoplasm into the nucleus (PubMed:28504655). {ECO:0000269|PubMed:16765102, ECO:0000269|PubMed:28504655}.
Protein families：