ERFE_MOUSE Q6PGN1
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UniProt:Q6PGN1
Recommended name：Erythroferrone
EC number：
Alternative names：(Complement C1q tumor necrosis factor-related protein 15) (Myonectin)
Cleaved into：
GeneID：227358
Gene names (primary )：Erfe
Gene names (synonym )：C1qtnf15 Ctrp15 Fam132b
Gene names (ORF )：
Length：340
Mass：36265
Sequence：MASTRRPVGARTLLACASLLAAMGLGVPESAEPVGTHARPQPPGAELPAPPANSPPEPTIAHAHSVDPRDAWMLFVKQSDKGINSKRRSKARRLKLGLPGPPGPPGPQGPPGPFIPSEVLLKEFQLLLKGAVRQRESHLEHCTRDLTTPASGSPSRVPAAQELDSQDPGALLALLAATLAQGPRAPRVEAAFHCRLRRDVQVDRRALHELGIYYLPEVEGAFHRGPGLNLTSGQYTAPVAGFYALAATLHVALTEQPRKGPTRPRDRLRLLICIQSLCQHNASLETVMGLENSSELFTISVNGVLYLQAGHYTSVFLDNASGSSLTVRSGSHFSAILLGL
Tissue specificity：Predominantly expressed in skeletal muscle and, at much lower levels, in other tissues, including lung, eye, smooth muscle, heart, brain and kidney. Within skeletal muscles, higher expression levels in soleus as compared with plantaris. Found in blood (at protein level). Following EPO treatment, only expressed in bone marrow and spleen (PubMed:24880340). Females tend to have higher circulating levels than males. Obese mice tend to have lower expression and circulating levels as compared to lean animals. {ECO:0000269|PubMed:22351773, ECO:0000269|PubMed:24880340}.
Induction：Up-regulated by intracellular increase in cAMP levels, such as those ellicited by forskolin and epinephrine treatments, and increase in calcium (ionomycine). Up-regulated by exercise in skeletal muscle (at the mRNA level) and blood (at protein level). Drastically down-regulated by fasting. Up-regulated in skeletal muscle by refeeding; the extent of induction by refeeding may be dependent upon the muscle fiber type, being much higher in soleus than in plantaris. Both glucose and lipid are equally potent in this induction, in the absence of any gut-derived hormones. Highly induced within 4 hours of bleeding (PubMed:24880340). {ECO:0000269|PubMed:22351773, ECO:0000269|PubMed:24880340}.
Developmental stage：In the myoblast C2C12 cell line, expression is increased upon differentiation into myotubes. {ECO:0000269|PubMed:22351773}.
Protein families：Adipolin/erythroferrone family