SMTL1_MOUSE Q99LM3
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UniProt:Q99LM3
Recommended name：Smoothelin-like protein 1
EC number：
Alternative names：(Calponin homology-associated smooth muscle protein) (CHASM)
Cleaved into：
GeneID：68678
Gene names (primary )：Smtnl1
Gene names (synonym )：
Gene names (ORF )：
Length：459
Mass：49525
Sequence：MEQTEGNSSEDGTTVSPTAGNLETPGSQGIAEEVAEGTVGTSDKEGPSDWAEHLCKAASKSGESGGSPGEASILDELKTDLQGEARGKDEAQGDLAEEKVGKEDTTAASQEDTGKKEETKPEPNEVREKEEAMLASEKQKVDEKETNLESKEKSDVNDKAKPEPKEDAGAEVTVNEAETESQEEADVKDQAKPELPEVDGKETGSDTKELVEPESPTEEQEQGKENESEERAAVIPSSPEEWPESPTDEGPSLSPDGLAPESTGETSPSASESSPSEVPGSPTEPQPSEKKKDRAPERRVSAPSRPRGPRAQNRKAIMDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTRNYEHVDIQNFSSSWSSGMAFCALIHKFFPEAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK
Tissue specificity：Widely expressed, with highest expression in skeletal muscles (at protein level). Within striated muscles, significantly more expressed in soleus muscle compared with plantaris muscle or white vastus (at protein level). 30-40% lower expression in females than in males (at protein level). Expressed in type 2a fibers, but not detected in fast twitch type 2b muscle white vastus nor in oxidative type I/b heart muscle (at protein level). Expressed within myometrial cells of the uterus, as well as in the endometrial layer. In the aorta, confined to smooth muscle cells. Not detected in endothelial cells. {ECO:0000269|PubMed:18310078, ECO:0000269|PubMed:20634291}.
Induction：Significantly reduced by exercise in smooth and in skeletal muscles. {ECO:0000269|PubMed:18310078}.
Developmental stage：Not detected in somites which give rise to skeletal muscle at 10.5 dpc (at protein level). Expressed in skeletal muscle of the tongue, diaphragm and axial muscles from 14.5 through 17.5 dpc (at protein level). Not detected in limb buds (at protein level). Overall increase by up to 10-12-fold in vascular and uterine smooth muscle during pregnancy (at protein level). At day 13 of pregnancy, expression increases in striated muscle by 2.5-fold compared with non-pregnant mice, and by about 2-fold over levels expressed in males (at protein level). At the same time, dramatically increased in myometrial cells of the uterus, in the endometrial layer and in aortal smooth muscle. Steadily declines through parturition and the onset of lactation (at protein level). {ECO:0000269|PubMed:18310078, ECO:0000269|PubMed:20634291}.
Protein families：Smoothelin family