NR4A3_MOUSE Q9QZB6
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UniProt:Q9QZB6
Recommended name：Nuclear receptor subfamily 4 group A member 3
EC number：
Alternative names：(Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma)
Cleaved into：
GeneID：18124
Gene names (primary )：Nr4a3
Gene names (synonym )：Tec
Gene names (ORF )：
Length：627
Mass：68454
Sequence：MPCVQAQYSPSPPGSTYATQTYGSEYTTEIMNPDYTKLTMDLGSTGIMATATTSLPSFSTFMEGYPSSCELKPSCLYQMPPSGPRPLIKMEEGREHGYHHHHHHHHHHHHHQQQQPSIPPPSGPEDEVLPSTSMYFKQSPPSTPTTPGFPPQAGALWDDELPSAPGCIAPGPLLDPQMKAVPPMAAAARFPIFFKPSPPHPPAPSPAGGHHLGYDPTAAAALSLPLGAAAAAGSQAAALEGHPYGLPLAKRTATLTFPPLGLTASPTASSLLGESPSLPSPPNRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRALTDATPRDLDYSRYCPTDQATAGTDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLRGFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMITERHGLKEPKRVEELCTKITSSLKDHQRKGQALEPSEPKVLRALVELRKICTQGLQRIFYLKLEDLVPPPSVIDKLFLDTLPF
Tissue specificity：Ubiquitous. Highest levels of expression in brain. Widely expressed throughout the arcuate nucleus region of the hypothalamus, namely in AgRP neurons.
Induction：Induced by inflammatory stimuli (PubMed:20558821). Up-regulated by the anorexigenic signal leptin via the transcription factor cyclic AMP response element-binding protein (CREB). Suppressed by orexigenic signal glucocorticoid that mobilizes NR3C1 to inhibit NR4A3 expression by antagonizing the action of CREB (PubMed:23897430). {ECO:0000269|PubMed:20558821, ECO:0000269|PubMed:23897430}.
Developmental stage：Not expressed during the earliest stages of vesicle formation (10.5 dpc). Expression begins coincidentally with the initiation of regional shape changes in the otic vesicle at 11.5 dpc and is restricted to the dorsolateral region. At 13.5 dpc, expression is limited to the inner edge of the semicircular canal epithelium, flanking the site of fusion, and this restricted expression continues at P1 (PubMed:11784868). At 14.5 dpc expression is observed in the primitive plexiform layer of the hippocampus. At P0, expression is observed in both the pyramidal and granule cell layers. Expression persistes in these cells in the adult hippocampus after their postnatal maturation. In addition, expression is also observed in the hilar mossy cells of the dentate gyrus (PubMed:15456880). At 7.5 dpc expression is ubiquitous, whereas at 9 dpc and 9.5 dpc, expression is restricted to the brain (PubMed:13129926). {ECO:0000269|PubMed:11784868, ECO:0000269|PubMed:13129926, ECO:0000269|PubMed:15456880}.
Protein families：Nuclear hormone receptor family, NR4 subfamily