SFRP4_MOUSE Q9Z1N6
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UniProt:Q9Z1N6
Recommended name:Secreted frizzled-related sequence protein 4
EC number:
Alternative names:(FRP-4) (sFRP-4)
Cleaved into:
GeneID:20379
Gene names (primary ):Sfrp4
Gene names (synonym ):
Gene names (ORF ):
Length:351
Mass:40342
Sequence:MLRSILVALCLWLRLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSSVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMMVQERSFDADCKRLSPDRCKCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSLSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYEWRSRMMLLENCLVEKWRDQLSRRSIQWEERLQEQQRTIQDKKQIASRTSRTSRSNPPKSKGRPPAPKPASPKKNIKARSAPKKSNLKKSAS
Tissue specificity:Expressed in the ovary. Localized to granulosa cells of periovulatory follicles and corpora lutea. Weakly expressed in adult tissues including kidney, brain and lung. {ECO:0000269|PubMed:12960062}.
Induction:Induced in ovaries by chorionic gonadotropin (CG). {ECO:0000269|PubMed:12960062}.
Developmental stage:Only weakly expressed in developing embryo except for developing teeth, eye and salivary gland. In the developing eye, from 12.5 dpc, expressed in the future neural retina, in both the inner and outer cell layers. In the developing teeth, strong expression detected in the developing incisor teeth at 14.5 dpc. Expression localized to the mesenchyme of the dental follicle surrounding the enamel organ only at the early cap stage. Highly expressed in the branching epithelium of the salivary gland. {ECO:0000269|PubMed:9739103}.
Protein families:Secreted frizzled-related protein (sFRP) family