CRUM1_MOUSE Q8VHS2
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UniProt:Q8VHS2
Recommended name：Protein crumbs homolog 1
EC number：
Alternative names：
Cleaved into：
GeneID：170788
Gene names (primary )：Crb1
Gene names (synonym )：
Gene names (ORF )：
Length：1405
Mass：153350
Sequence：MKLKRTAYLLFLYLSSSLLICIKNSFCNKNNTRCLSGPCQNNSTCKHFPQDNNCCLDTANNLDKDCEDLKDPCFSSPCQGIATCVKIPGEGNFLCQCPPGYSGLNCETATNSCGGNLCQHGGTCRKDPEHPVCICPPGYAGRFCETDHNECASSPCHNGAMCQDGINGYSCFCVPGYQGRHCDLEVDECVSDPCKNEAVCLNEIGRYTCVCPQEFSGVNCELEIDECRSQPCLHGATCQDAPGGYSCDCAPGFLGEHCELSVNECESQPCLHGGLCVDGRNSYHCDCTGSGFTGMHCESLIPLCWSKPCHNDATCEDTVDSYICHCRPGYTGALCETDINECSSNPCQFWGECVELSSEGLYGNTAGLPSSFSYVGASGYVCICQPGFTGIHCEEDVDECLLHPCLNGGTCENLPGNYACHCPFDDTSRTFYGGENCSEILLGCTHHQCLNNGKCIPHFQNGQHGFTCQCLSGYAGPLCETVTTLSFGSNGFLWVTSGSHTGIGPECNISLRFHTVQPNALLLIRGNKDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTIAETLTLALVGGSCKEKCTTKSSVPVENHQSICALQDSFLGGLPMGTANNSVSVLNIYNVPSTPSFVGCLQDIRFDLNHITLENVSSGLSSNVKAGCLGKDWCESQPCQNRGRCINLWQGYQCECDRPYTGSNCLKEYVAGRFGQDDSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFFLSDGNVHLISLRIKPNEIELYQSSQNLGFISVPTWTIRRGDVIFIGGLPDREKTEVYGGFFKGCVQDVRLNSQTLEFFPNSTNNAYDDPILVNVTQGCPGDNTCKSNPCHNGGVCHSLWDDFSCSCPTNTAGRACEQVQWCQLSPCPPTAECQLLPQGFECIANAVFSGLSREILFRSNGNITRELTNITFAFRTHDTNVMILHAEKEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLVNDGTWHQVTFSMIDPVAQTSRWQMEVNDQTPFVISEVATGSLNFLKDNTDIYVGDQSVDNPKGLQGCLSTIEIGGIYLSYFENLHGFPGKPQEEQFLKVSTNMVLTGCLPSNACHSSPCLHGGNCEDSYSSYRCACLSGWSGTHCEINIDECFSSPCIHGNCSDGVAAYHCRCEPGYTGVNCEVDVDNCKSHQCANGATCVPEAHGYSCLCFGNFTGRFCRHSRLPSTVCGNEKRNFTCYNGGSCSMFQEDWQCMCWPGFTGEWCEEDINECASDPCINGGLCRDLVNRFLCICDVAFAGERCELDLADDRLLGIFTAVGSGTLALFFILLLAGVASLIASNKRATQGTYSPSGQEKAGPRVEMWIRMPPPALERLI
Tissue specificity：[Isoform 1]: Expressed in the kidney, lung, stomach and testis (PubMed:14684155). Expressed in the brain and eye (PubMed:11744384, PubMed:14684155). Expressed in the outer nuclear layer, photoreceptor layer and inner nuclear layer of the retina (PubMed:11744384). Expressed in Mueller cell radial processes in the inner nuclear layer, in apical processes sclerad to the external limiting membrane, and in the subapical region, adjacent to the adherens junction of retinal photoreceptors (PubMed:12915475, PubMed:15316081). In the brain, expressed in the granular layer of the cerebellum, the hippocampal dentate gyrus, the olfactory bulbs, the subventricular region lining the telencephalic ventricles and the rostral migratory stream (PubMed:11744384). {ECO:0000269|PubMed:11744384, ECO:0000269|PubMed:12915475, ECO:0000269|PubMed:14684155, ECO:0000269|PubMed:15316081}.; [Isoform 3]: Ubiquitously expressed. {ECO:0000269|PubMed:14684155}.
Induction：
Developmental stage：Primarily detected in the central nervous system at 10.5 dpc, in the ventral part of the neural tube including the ventral spinal cord, the ventral part of the mesencephalon, the mammillary and the hypothalamic regions, the optic area and the zona limitans intrathalamica (PubMed:11744384). Expressed by the V3 interneurons placed between the floor plate and the motorneurons all along the spinal cord axis (PubMed:11744384). In late embryogenesis, expressed mainly in ventral neural structures of the developing brain, including the mammillary, tuberalis regions of the hypothalamus and the preoptic area (PubMed:11744384). Starting from 12.5 dpc, also strongly expressed in the neural area that gives rise to the dorsal thalamus (PubMed:11744384). In the retina, expression starts at 11.5 dpc and is enhanced at 12.5, 14.5 and 16.5 dpc (PubMed:11744384). In postnatal stages, abundant expression in photoreceptors and also found in the inner nuclear layer and iris (PubMed:11744384). {ECO:0000269|PubMed:11744384}.; [Isoform 3]: Expression first detected at 14 dpc, expression is enhanced at 15 and 16 dpc during active proliferation of epidermal cells, decreases after birth, but is maintained in adult skin (PubMed:14684155). Detected in the skin basal cells at 16 dpc, it was observed in upper layers after birth (at protein level) (PubMed:14684155). {ECO:0000269|PubMed:14684155}.
Protein families：Crumbs protein family