IL31R_MOUSE Q8K5B1
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UniProt:Q8K5B1
Recommended name：Interleukin-31 receptor subunit alpha
EC number：
Alternative names：(IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (GLM-R) (mGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (Novel cytokine receptor 10) (NR10) (ZcytoR17)
Cleaved into：
GeneID：218624
Gene names (primary )：Il31ra
Gene names (synonym )：Glmr
Gene names (ORF )：
Length：716
Mass：80580
Sequence：MWTLALWAFSFLCKFSLAVLPTKPENISCVFYFDRNLTCTWRPEKETNDTSYIVTLTYSYGKSNYSDNATEASYSFPRSCAMPPDICSVEVQAQNGDGKVKSDITYWHLISIAKTEPPIILSVNPICNRMFQIQWKPREKTRGFPLVCMLRFRTVNSSHWTEVNFENCKQVCNLTGLQAFTEYVLALRFRFNDSRYWSKWSKEETRVTMEEVPHVLDLWRILEPADMNGDRKVRLLWKKARGAPVLEKTFGYHIQYFAENSTNLTEINNITTQQYELLLMSQAHSVSVTSFNSLGKSQEAILRIPDVHEKTFQYIKSMKAYIAEPLLVVNWQSSIPAVDTWIVEWLPEAAMSKFPALSWESVSQVTNWTIEQDKLKPFTCYNISVYPVLGHRVGEPYSIQAYAKEGTPLKGPETRVENIGLRTATITWKEIPKSARNGFINNYTVFYQAEGGKELSKTVNSHALQCDLESLTRRTSYTVWVMASTRAGGTNGVRINFKTLSISVFEIVLLTSLVGGGLLLLSIKTVTFGLRKPNRLTPLCCPDVPNPAESSLATWLGDGFKKSNMKETGNSGDTEDVVLKPCPVPADLIDKLVVNFENFLEVVLTEEAGKGQASILGGEANEYVTSPSRPDGPPGKSFKEPSVLTEVASEDSHSTCSRMADEAYSELARQPSSSCQSPGLSPPREDQAQNPYLKNSVTTREFLVHENIPEHSKGEV
Tissue specificity：Expressed in a subset of dorsal root ganglia neurons (PubMed:16926070, PubMed:24373353, PubMed:25381841). Expressed in spinal cord and trigeminal ganglion (at protein level) (PubMed:25381841). Expressed in skin, testis, bone marrow and thymus (PubMed:15184896). {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:16926070, ECO:0000269|PubMed:24373353, ECO:0000269|PubMed:25381841}.
Induction：Up-regulated in the diseased tissues of a mouse models of allergic asthma and airway hypersensitivity (PubMed:15184896, PubMed:25847241). Up-regulated by IL31 in dorsal root ganglia (PubMed:25381841). Up-regulated by Th2 cytokines IL4 and IL13 in macrophages (PubMed:25847241). {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:25381841, ECO:0000269|PubMed:25847241}.
Developmental stage：Primarily expressed at postnatal day 10 in the dorsal root ganglia where expression gradually increases as the development proceed. {ECO:0000269|PubMed:16926070}.
Protein families：Type I cytokine receptor family, Type 2 subfamily