TLE6_MOUSE Q9WVB3
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UniProt:Q9WVB3
Recommended name：Transducin-like enhancer protein 6
EC number：
Alternative names：(Groucho-related protein 6)
Cleaved into：
GeneID：114606
Gene names (primary )：Tle6
Gene names (synonym )：Grg6
Gene names (ORF )：
Length：581
Mass：65116
Sequence：MTSHRQSSDTFGGILPSTLSSRYLSIVNQLPEEFSSVVSEMMVHLENIFSLAENFFQAIERFSRTPDLLERNKMSIGVGAEGDSWPCHVSHEAPMGSAQTTENSAKEEDKQVPESAALQHPKFKSTPGPQLPTRRRFLSESDELQDPQPVWDAEPQFCQGFLIQGLWELFMDSRQKNQQEHGGEDSSQESKDSGLCDFKPEPQPRHRNSLSDSADPFLIKSPSALLDYYQEDVSRPQPETQESSGRADKFLKPLSWGSEVLESSCNQPSTALWQLERFTVPQALQKVRVLKHQELLLVVAVSSFTRHVFTCSQSGIKVWNLVNQVAEDRDPESHLKCSVQDNKVYLRTCLLSSNSRTLFAGGYNLPGVIVWDLAAPSLYEKCQLPCEGLSCQALANTKENMALAGFTDGTVRIWDLRTQEIVRNLKGPTNSARNLVVKDDNIWTGGLDACLRCWDLRMAKVSLEHLFQSQIMSLAHSPTEDWLLLGLANGQHCLFNSRKRDQVLTVDTKDNTILGLKFSPNGKWWASVGMGNFITVHSMPTGAKLFQVPEVGPVRCFDMTENGRLIITGSRDCASVYHIKY
Tissue specificity：Expressed predominantly in ovaries, where it is restricted to growing oocytes, with greatest levels in fully grown oocytes (PubMed:18804437). Expressed predominantly in testis, heart, lung, liver and muscle, and at very low levels in the brain, spleen and kidney (PubMed:11486032). {ECO:0000269|PubMed:11486032, ECO:0000269|PubMed:18804437}.
Induction：Induced by E2A-HLF, a chimeric transcription factor containing the transactivation domain of E2A linked to the DNA-binding and dimerization domain of HLF. {ECO:0000269|PubMed:11486032}.
Developmental stage：Transcripts first detected at 15.5 dpc and peak 1 week after birth. Transcripts accumulate during oogenesis (PubMed:18804437). During meiotic maturation, the vast majority of the transcripts are degraded and virtually none is detected by 2-cell stage embryogenesis (PubMed:18804437). The protein however persists during preimplantation up to the blastocyst stage (PubMed:18804437). At 2-cell stage, excluded from cell-cell contact regions. Continuous exclusion from these regions during preimplantation development leads to the absence of the protein from the inner cells of the morula and the inner cell mass of the blastocyst (PubMed:18804437). {ECO:0000269|PubMed:18804437}.
Protein families：WD repeat Groucho/TLE family