REST_MOUSE Q8VIG1
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UniProt:Q8VIG1
Recommended name：RE1-silencing transcription factor
EC number：
Alternative names：(Neural-restrictive silencer factor)
Cleaved into：
GeneID：19712
Gene names (primary )：Rest
Gene names (synonym )：Nrsf
Gene names (ORF )：
Length：1082
Mass：117784
Sequence：MATQVMGQSSGGGSLFNNSANMGMALTNDMYDLHELSKAELAAPQLIMLANVALTGEASGSCCDYLVGEERQMAELMPVGDNHFSESEGEGLEESADLKGLENMELGSLELSAVEPQPVFEASAAPEIYSANKDPAPETPVAEDKCRSSKAKPFRCKPCQYEAESEEQFVHHIRIHSAKKFFVEESAEKQAKAWESGSSPAEEGEFSKGPIRCDRCGYNTNRYDHYMAHLKHHLRAGENERIYKCIICTYTTVSEYHWRKHLRNHFPRKVYTCSKCNYFSDRKNNYVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCNYVASNQHEVTRHARQVHNGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPSKTMDVSKVKLKKTKKREADLLNNAVSNEKMENEQTKTKGDVSGKKNEKPVKAVGKDASKEKKPGSSVSVVQVTTRTRKSAVAAETKAAEVKHTDGQTGNNPEKPCKAKKNKRKKDAEAHPSEEPVNEGPVTKKKKKSECKSKIGTNVPKGGGRAEERPGVKKQSASLKKGTKKTPPKTKTSKKGGKLAPKGMGQTEPSSGALAQVGVSPDPALIQAEVTGSGSSQTELPSPMDIAKSEPAQMEVSLTGPPPVEPAQMEPSPAKPPQVEAPTYPQPPQRGPAPPTGPAPPTGPAPPTEPAPPTGLAEMEPSPTEPSQKEPPPSMEPPCPEELPQAEPPPMEDCQKELPSPVEPAQIEVAQTAPTQVQEEPPPVSEPPRVKPTKRSSLRKDRAEKELSLLSEMARQEQVLMGVGLVPVRDSKLLKGNKSAQDPPAPPSPSPKGNSREETPKDQEMVSDGEGTIVFPLKKGGPEEAGESPAELAALKESARVSSSEQNSAMPEGGASHSKCQTGSSGLCDVDTEQKTDTVPMKDSAAEPVSPPTPTVDRDAGSPAVVASPPITLAENESQEIDEDEGIHSHDGSDLSDNMSEGSDDSGLHGARPTPPEATSKNGKAGLAGKVTEGEFVCIFCDRSFRKEKDYSKHLNRHLVNVYFLEEAAEEQEEQEEREEQE
Tissue specificity：Expressed in the hippocampus, including quiescent neuronal progenitor (QNP) cells, transient-amplifying progenitor (TAP) cells, neuroblasts and mature neurons (at protein level) (PubMed:27819263). Expressed in embryonic stem cells (at protein level) (PubMed:15907476). Expressed in many non-neuronal tissues including the heart and liver (PubMed:7871435). Abundantly expressed in osteoblastic lineage cells (PubMed:25727884). Expressed in the spleen, kidney, blood cells, cortex, neocortex and in the utricle, saccule and organ of Corti of the inner ear (PubMed:29961578). Isoform 2: Expressed in the cortex, neocortex and in the utricle, saccule and organ of Corti of the inner ear (PubMed:29961578). {ECO:0000269|PubMed:15907476, ECO:0000269|PubMed:25727884, ECO:0000269|PubMed:27819263, ECO:0000269|PubMed:29961578, ECO:0000269|PubMed:7871435}.
Induction：Down-regulated in differentiating neurons and mature neurons. {ECO:0000269|PubMed:15907476}.
Developmental stage：Ubiquitously expressed in 8.5 dpc and 9.5 dpc embryos (PubMed:9771705). During embryogenesis, expressed at high levels in non-neuronal and differentiated peripheral nervous tissues, but is not expressed in differentiating neurons in the CNS (PubMed:7697725, PubMed:7871435). Expressed in the neocortex at embryonic stage 14.5 dpc and 16 dpc and in the utricle at 15.5 dpc (PubMed:29961578). Isoform 2: Expressed in the neocortex at embryonic stage 14.5 dpc and 16 dpc and in the utricle and saccule at 16 dpc (PubMed:29961578). {ECO:0000269|PubMed:29961578, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:9771705}.
Protein families：