NSD2_MOUSE Q8BVE8
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UniProt:Q8BVE8
Recommended name：Histone-lysine N-methyltransferase NSD2
EC number：EC 2.1.1.357
Alternative names：(Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Wolf-Hirschhorn syndrome candidate 1 protein homolog)
Cleaved into：
GeneID：107823
Gene names (primary )：Nsd2
Gene names (synonym )：Kiaa1090 Whsc1
Gene names (ORF )：
Length：1365
Mass：152253
Sequence：MEFSIRKSPLSVQKVVKCMKMKQTPEILGSANGKTQNCEVNHECSVFLSKAQLSNSLQEGVMQKFNGHDALPFLPAEKLKDLTSCVFNGEPGAHDTKLCFEAQEVKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDGAADVSQSEENEQKSDNKTRRNRKRSIKYDSLLEQGLVEAALVSKISSPADKKIPVKKESCPNTGRDRDLLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRAQWEMGIVQAEEAASMSIEERKAKFTFLYVGDQLHLNPQVAKEAGIVTEPLGEMVDSSGASEEAAVDPGSVREEDIPTKRRRRTKRSSSAENQEGDPGTDKSTPPKMAEAEPKRGVGSPAGRKKSTGSAPRSRKGDSAAQFLVFCQKHRDEVVAEHPDASGEEIEELLGSQWSMLNEKQKARYNTKFSLMISAQSEEDSGNGNGKKRSHTKRADDPAEDVDVEDAPRKRLRADKHSLRKRETITDKTARTSSYKAIEAASSLKSQAATKNLSDACKPLKKRNRASATASSALGFNKSSSPSASLTEHEVSDSPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEYVCQLCEKTGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCKESKMEVKRCVVNQCGKFYHEACVKKYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTARKGKRHHTHVNVSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTEKPFPESLKSKGKRKKRRCWRRVTDGK
Tissue specificity：During B-cell development, expressed in early B2 cell progenitors (pre- and pro-B cells) with a decrease in expression at later stages. {ECO:0000269|PubMed:32862441}.
Induction：Induced in CD4(+) T-cell in response to T-cell receptor (TCR) and CD28 stimulation (at protein level) (PubMed:31636135). Induced in B2-cells by IgM antibodies or lipopolysaccharide (LPS) stimulation (PubMed:32862441). {ECO:0000269|PubMed:31636135, ECO:0000269|PubMed:32862441}.
Developmental stage：Ubiquitously expressed in early development (PubMed:9618163). Highly expressed in neuroepithelium at 10.5 dpc, and in the forebrain, midbrain, frontal facial region, jaw, heart but not in the endocardial cushion, and cartilage primordial at 14.5 dpc (PubMed:19483677). {ECO:0000269|PubMed:19483677, ECO:0000269|PubMed:9618163}.
Protein families：Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily