PPE1_MOUSE O35655
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UniProt:O35655
Recommended name：Serine/threonine-protein phosphatase with EF-hands 1
EC number：EC 3.1.3.16
Alternative names：(PPEF-1) (DRES10) (Protein phosphatase with EF calcium-binding domain) (PPEF)
Cleaved into：
GeneID：237178
Gene names (primary )：Ppef1
Gene names (synonym )：Dres10 Ppef
Gene names (ORF )：
Length：650
Mass：75058
Sequence：MGCGTSSKKGNKSKKVIKAALVIQNWYRRYRARLRVRQHYALAIFQSIEYSDEQGQMQLSSFFSFMLENYTKTNNEDSALVTRIFDNTRRESQIKDRDDFLGLIEVPDSYDGPRLQFPLTFTDIHILLQAFKQQQILHAHYVLEVLFEARKVLKQMPNFSHVKTFPAKEITICGDLHGKLDDLMLIFYKNGLPSENNPYVFNGDFVDRGNNSMEILMILLVCFLVYPSDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGRKILQVLEEVYTWLPIGTIIDNEILVIHGGISESTDLNTLHQLQRNKMKSVLMPPVLGNQETGEKRNKSASNYVEPRKVEPDKTPSEDLTKQEWEQIVDILWSDPRGKKGCYPNTSRGGGCYFGPDVTSKVLSKNQLKMLIRSHECKPDGYEVSHDGKVITVFSASNYYEEGSNRGAYIRLSYGTMPQFFQYQVTSTSCLNPLHQRMNAMESSAFKILKEKMISRKTDLINAFELRDHSRSGRISLAEWAFSMENILGLNLPWRSLSSHLVTIDSSGSVDYMSSFDDIRIEKPTKDMKSNLTETMYRYRSDLKIIFNIIDSDQSGLISMDEFRTMWKLFNAHYKAHIDDSQIDELASIVDFNKDGNIDFNEFLKAFYVVHKYDKPGTSLA
Tissue specificity：In the embryo it is almost exclusively expressed in the peripheral nervous system, within sensory neurons of cranial and dorsal root ganglia. Otherwise found in fetal inner ear and a small group of neurons in the midbrain/pons junction.
Induction：
Developmental stage：Up-regulated at 12.3 dpc in dorsal root ganglia (DRG) and in some sensory cranial ganglia. A slightly decreased expression could still be detected in sensory ganglia at 16.5 dpc. It is not known if expression in sensory neurons persists in adult life.
Protein families：PPP phosphatase family