RETST_MOUSE Q64FW2
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UniProt:Q64FW2
Recommended name：All-trans-retinol 13,14-reductase
EC number：EC 1.3.99.23
Alternative names：(All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein)
Cleaved into：
GeneID：67442
Gene names (primary )：Retsat
Gene names (synonym )：Ppsig
Gene names (ORF )：
Length：609
Mass：67334
Sequence：MWITALLLAVLLLVILHRVYVGLYAASSPNPFAEDVKRPPEPLVTDKEARKKVLKQAFSVSRVPEKLDAVVIGSGIGGLASAAVLAKAGKRVLVLEQHTKAGGCCHTFGENGLEFDTGIHYIGRMREGNIGRFILDQITEGQLDWAPMASPFDLMILEGPNGRKEFPMYSGRKEYIQGLKKKFPKEEAVIDKYMELVKVVARGVSHAVLLKFLPLPLTQLLSKFGLLTRFSPFCRASTQSLAEVLQQLGASRELQAVLSYIFPTYGVTPSHTAFSLHALLVDHYIQGAYYPRGGSSEIAFHTIPLIQRAGGAVLTRATVQSVLLDSAGRACGVSVKKGQELVNIYCPVVISNAGMFNTYQHLLPETVRHLPDVKKQLAMVRPGLSMLSIFICLKGTKEDLKLQSTNYYVYFDTDMDKAMERYVSMPKEKAPEHIPLLFIAFPSSKDPTWEERFPDRSTMTALVPMAFEWFEEWQEEPKGKRGVDYETLKNAFVEASMSVIMKLFPQLEGKVESVTGGSPLTNQYYLAAPRGATYGADHDLARLHPHAMASIRAQTPIPNLYLTGQDIFTCGLMGALQGALLCSSAILKRNLYSDLQALGSKVKAQKKKM
Tissue specificity：Predominantly expressed in the liver (at protein level) (PubMed:19940255). Also expressed at high levels in kidney, intestine, and white fat and brown fat (PubMed:15358783, PubMed:18289917, PubMed:19139408, PubMed:28855500). Weakly expressed in heart, skeletal muscle and testis and barely detected in the lung, brain and spleen (PubMed:15358783, PubMed:18289917, PubMed:28855500). Up-regulated in the liver of diet-induced obese mice, compared to lean animals (PubMed:28855500). Down-regulated in adipose tissue of obese mice; this decrease could be due to the impact of inflammatory cells on adipocytes (PubMed:19139408). {ECO:0000269|PubMed:15358783, ECO:0000269|PubMed:18289917, ECO:0000269|PubMed:19139408, ECO:0000269|PubMed:19940255, ECO:0000269|PubMed:28855500}.
Induction：Up-regulated during starvation (PubMed:18289917). Up-regulated by PPARG (PubMed:19139408). {ECO:0000269|PubMed:18289917, ECO:0000269|PubMed:19139408}.
Developmental stage：Up-regulated during adipocyte differentiation in a 3T3-L1 cell culture model (at protein level). {ECO:0000269|PubMed:19139408, ECO:0000269|PubMed:19940255}.
Protein families：Carotenoid/retinoid oxidoreductase family, CrtISO subfamily