ACOD1_MOUSE P13516
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UniProt:P13516
Recommended name：Acyl-CoA desaturase 1
EC number：EC 1.14.19.1
Alternative names：(Delta(9)-desaturase 1) (Delta-9 desaturase 1) (Fatty acid desaturase 1) (Stearoyl-CoA desaturase 1)
Cleaved into：
GeneID：20249
Gene names (primary )：Scd1
Gene names (synonym )：
Gene names (ORF )：
Length：355
Mass：41046
Sequence：MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
Tissue specificity：Detected in liver (at protein level) (PubMed:10899171, PubMed:11533264). Detected in skin and liver (PubMed:10545940, PubMed:11161812, PubMed:11441127, PubMed:11533264). Detected in sebaceous gland, but not in hair follicle (PubMed:10545940). Detected in white and brown adipose tissue, eyelid, Harderian gland, and at lower levels in Meibomian gland, eyeball and adrenal gland (PubMed:11500518, PubMed:11533264). Highly expressed in liver, and detected at low levels in brain, heart, lung, stomach, skeletal muscle and kidney (PubMed:11161812, PubMed:12815040). {ECO:0000269|PubMed:10545940, ECO:0000269|PubMed:10899171, ECO:0000269|PubMed:11441127, ECO:0000269|PubMed:11500518, ECO:0000269|PubMed:11533264, ECO:0000269|PubMed:12815040}.
Induction：Up-regulated by agonists that activate NR1H3 (PubMed:12815040). Up-regulated by a high-carbohydrate diet (PubMed:11441127). Up-regulated by a fat-free, high-carbohydrate diet (PubMed:12815040). Down-regulated by a high-carbohydrate diet enriched in unsaturated fatty acids (PubMed:12815040). Up-regulated by a diet containing high levels of stearate (PubMed:17127673). {ECO:0000269|PubMed:11441127, ECO:0000269|PubMed:12815040, ECO:0000269|PubMed:17127673}.
Developmental stage：Up-regulated during the early anagen phase of the hair cycle. Thereafter, levels decrease and are very low at telogen phase. {ECO:0000269|PubMed:10545940, ECO:0000269|PubMed:11161812}.
Protein families：Fatty acid desaturase type 1 family