Anti-idiotype Antibody Services
Blocking (Type 1), Non-blocking (Type 2), and Complex-specific (Type 3) anti-ID antibodies
Develop high-affinity anti-idiotype antibodies for your therapeutic programs—biologics, ADCs, bispecifics, VHH, and more. Choose from rabbit monoclonal and mouse monoclonal formats. Fast turnaround from 7 weeks.
Three Types of Anti-idiotype Antibodies
Select the right anti-ID format based on your drug target and assay requirements (PK, ADA, or immunogenicity).
- For cell-bound targets (e.g., PD1/PDL1), Type 1 or Type 2 can be applied
- For soluble targets (e.g., TNF), both Type 1 & Type 2 may be needed
- Preferred when you need to measure total drug concentration regardless of target binding
- Essential for studying target occupancy and pharmacodynamics
For most therapeutic antibody programs, we recommend developing both Type 1 (blocking) and Type 2 (non-blocking) anti-ID antibodies to enable comprehensive PK/ADA assay development.
Anti-idiotype Antibody Service Packages
Tailored packages for different target types and formats. All services include immunogen preparation, animal immunization, screening, and guaranteed deliverables.
🐇 Rabbit Anti-ID Monoclonal Antibody Package
| Phase | Full-length IgG / ADC / Bi-specific Ab | scFv / VHH / (Neo)peptide / Protein / Small Molecule / VLP / RNA / Cell |
|---|---|---|
| Phase I: Immunogen Prep | F(ab')₂ preparation or whole antibody/ADC | KLH/BSA conjugation or whole protein/cell |
| Phase II: Immunization | Conventional protocol or rapid protocol | |
| Phase III: B Cell Cloning & Screening | • Indirect ELISA • Blocking ELISA* (required for Type 1 screening) | |
| Phase IV: Sequencing & rAb Production | • 5 clones sequencing reports • Guaranteed 0.1 mg recombinant antibody production • ELISA validation (with/without blocker & non-blocker) | |
| Turnaround Time | Starting from 9 weeks | |
🐭 Mouse Anti-ID Monoclonal Antibody Package
| Phase | Full-length IgG / ADC / Bi-specific Ab | scFv / VHH / RNA / VLP / (Neo)peptide / Protein / Small Molecule / Cell |
|---|---|---|
| Phase I: Immunogen Prep | F(ab')₂ preparation | KLH conjugation / Fab preparation |
| Phase II: Immunization | Conventional protocol or rapid protocol | |
| Phase III: Cell Fusion & Screening | • Cell fusion and subcloning • Deliver supernatants of 10 clones • Confirm anti-ID type (blocking/non-blocking) | |
| Phase IV: Antibody Production | Option 1 (Preferred): Sequencing & rAb • 5 clones sequencing • Guaranteed 0.1 mg recombinant production & ELISA validation Option 2: Hybridoma Production • Subcloning for up to 5 clones • Clone storage (optional) • Hybridoma production & purification | |
| Turnaround Time | Starting from 13 weeks | |
Simple Quotation & Ordering
Consultation
TAM contacts you within 24h for strategy and quote.
Approval
Review and approve final order details and price.
Project Start
Project initiated; PM provides updates until delivery.
Start Your Monoclonal Project
To discuss your target and receive a customized proposal, please email order@enkilife.com. Our team is ready to assist you right away.