Product List

AFP (1J18) Rabbit Monoclonal Antibody

Size:50μL Price:$128
Size:100μL Price:$230
Size:200μL Price:$380
Application:WB,IHC,IP,IF-P
Reactivity:Human
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:AFP

SKU: AMRe06665

Detail

Summary

Production Name	AFP (1J18) Rabbit Monoclonal Antibody
Description	Recombinant rabbit monoclonal antibody
Host	Rabbit
Application	WB,IHC,IP,IF-P
Reactivity	Human

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG
Clonality	Monoclonal
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Purification	Affinity purification

Immunogen

Gene Name	AFP
Alternative Names	Alpha fetoglobulin; Alpha fetoprotein precursor; FETA; HPAFP;
Gene ID	174
SwissProt ID	P02771

Application

Dilution Ratio	WB 1:500-1:2000,IHC 1:50-1:200,IP 1:20-1:50,IF-P 1:50-1:200
Molecular Weight	69kDa

Background

Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the mammalian fetal liver, yolk sac, and GI tract. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Research studies have shown that elevated serum AFP levels are predictive of hepatocellular carcinoma . Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.

Research Area

Cancer