Neurotrophic Factors
Limiting quantities of neurotrophins during development control the numbers of surviving neurons to ensure a match between neurons and the requirement for a suitable density of target innervation. Biological effects of each of the four mammalian neurotrophins are mediated through activation of one or more of the three members of the tropomyosin-related kinase (Trk) family of receptor tyrosine kinases (TrkA, TrkB, and TrkC). In addition, all neurotrophins activate the p75 neurotrophin receptor (p75NTR), a member of the tumor necrosis factor receptor superfamily. Neurotrophin engagement of Trk receptors leads to activation of Ras, phosphatidylinositol 3-kinase, phospholipase C-γ1, and signaling pathways controlled through these proteins, including the mitogen-activated protein kinases. Neurotrophin availability is required into adulthood, where they control synaptic function and plasticity and sustain neuronal cell survival, morphology, and differentiation.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
| Beta-NGF (Mammalian) | PHH1902 | Recombinant Human Beta-NGF (Mammalian) | Human | 13.3 KDa |
| NRN1L (C-6His) | PHH1242 | Recombinant Human NRN1L (C-6His) | Human | 12.3 KDa |
| CDNF (C-6His) | PHH0389 | Recombinant Human CDNF (C-6His) | Human | 19.3 KDa |
| BDNF | PEV0147 | Recombinant Human/Murine/Rat BDNF | Human/Mouse/Rat | 13 KDa |
| Beta-NGF (110AA) | PEM0151 | Recombinant Mouse Beta-NGF (110AA) | Mouse | 12.4 KDa |
| NT-3 | PEH1860 | Recombinant Human NT-3 | Human | 13.6 KDa |
| Beta-NGF | PEH1225 | Recombinant Human Beta-NGF | Human | 13.4 KDa |
| pro-Beta NGF | PEH1224 | Recombinant Human pro-Beta NGF | Human | 25 KDa |
| Neurturin | PEH1218 | Recombinant Human Neurturin | Human | 11.8 KDa |
| Neuritin (N-6His) | PEH1210 | Recombinant Human Neuritin (N-6His) | Human | 12.1 KDa |
| GDNF | PEH0723 | Recombinant Human GDNF | Human | 15.1 KDa |
| pro-BDNF | PEH0146 | Recombinant Human pro-BDNF | Human | 25.6 KDa |
Validation Data
Related Products
Super-sensitive ECL chemiluminescent reagent
References
1. Neurotrophic Factors: An Overview. Skaper SD. Methods Mol Biol. 2018. [PMID: 29222769]
2. Neurotrophic factors in multiple sclerosis. Güner F, et al. Front Immunol. 2025. [PMID: 40936917]
