Tumor Necrosis Factor Receptor Superfamily (TNFRSF)
The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptorseither induce cell death or promote cell survival of immune cells. The number of recognized members of the TNF receptor and ligand superfamily has expanded substantially in the last several years. More important, the biologic function of this group of proteins has been closely associated with the regulation of the immune respon se and the pathogene isis of autoimmune disease. Thus, the direct targeting of these receptorsby either inducing apoptosisorblocking survival of autoimmune T and B cells may be an im portant therapeutic strategy in the treatment of autoimmune disease.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
| OPG (C-10His) | PHM1747 | Recombinant Mouse OPG (C-10His) | Mouse | 45.1 KDa |
| OPG (C-Fc) | PHH1674 | Recombinant Human OPG (C-Fc) | Human | 47.2 KDa |
| RELT (C-Fc) | PHH1423 | Recombinant Human RELT (C-Fc) | Human | 41.4 KDa |
| OPG (C-6His) | PHH1255 | Recombinant Human OPG (C-6His) | Human | 44.65 KDa |
Validation Data
Recombinant Mouse OPG (C-10His) (Catalog: PHM1747) Recombinant Human OPG (C-6His) (Catalog: PHH1255)
Related Products
Super-sensitive ECL chemiluminescent reagent
References
1. Tumor necrosis factor receptor superfamily members and their ligands. Armitage RJ. Curr Opin Immunol. 1994. [PMID: 7917108]
2. Immunobiology of tumor necrosis factor receptor superfamily. Zhou T,et al. Immunol Res. 2002. [PMID: 12403370]
3. Tumor necrosis factor receptor superfamily. Naismith JH, et al. J Inflamm. 1995. [PMID: 8913924]
4. The benefits of clustering in TNF receptor superfamily signaling. Vanamee ÉS, et al. Front Immunol. 2023. [PMID: 37662920]
