Fibroblast Growth Factors (FGFs)
The Fibroblast Growth Factor (FGF) family comprises a group of structurally related signaling proteins that play crucial roles in embryonic development, cell proliferation, differentiation, migration, angiogenesis, tissue repair, and metabolic regulation. In humans, the FGF family includes 18 canonical members (FGF1–FGF10 and FGF16–FGF23), which are classified into six subfamilies based on sequence homology and functional characteristics. While most FGFs act locally in a paracrine manner, the FGF19 subfamily (FGF19, FGF21, and FGF23) functions endocrinely, regulating systemic metabolism of bile acids, glucose, and phosphate. FGFs exert their effects by binding to FGF receptors (FGFRs), activating downstream signaling pathways such as MAPK and PI3K/AKT, thereby influencing various cellular processes.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
| FGF-21 (C-6His) | PHV0660 | Recombinant Cynomolgus FGF-21 (C-6His) | Cynomolgus | 20.2 KDa |
| FGF-21 (C-6His) | PHM2199 | Recombinant Mouse FGF-21 (C-6His) | Mouse | 20.8 KDa |
| FGF-17 (C-6His) | PHH1900 | Recombinant Human FGF-17 (C-6His) | Human | 22.64 KDa |
| KGF (C-6His) | PHH0662 | Recombinant Human KGF (C-6His) | Human | 20 KDa |
| FGF-8b | PEV0663 | Recombinant Human/Mouse FGF-8b | Human/Mouse | 22.5 KDa |
| FGFb | PER0657 | Recombinant Rat FGFb | Rat | 16.2 KDa |
| FGF-4 | PEM2172 | Recombinant Mouse FGF-4 | Mouse | 15.2 KDa |
| FGF-9 (C-6His) | PEM0664 | Recombinant Mouse FGF-9 (C-6His) | Mouse | 24.4 KDa |
| FGFb | PEM0647 | Recombinant Mouse FGFb | Mouse | 17.15 KDa |
| FGF-4 (136AA) | PEH2174 | Recombinant Human FGF-4 (136AA) | Human | 15.1 KDa |
| FGF-4 (153AA) | PEH0661 | Recombinant Human FGF-4 (153AA) | Human | 16.9 KDa |
| FGFb (Q65I,C96S,N111G) | PEH0659 | Recombinant Human FGFb (Q65I,C96S,N111G) | Human | 17.2 KDa |
| FGFb(K128N) | PEH0658 | Recombinant Human FGFb(K128N) | Human | 17.2 KDa |
| FGF-10 | PEH0656 | Recombinant Human FGF-10 | Human | 19.5 KDa |
| FGF-9 | PEH0653 | Recombinant Human FGF-9 | Human | 23.44 KDa |
| KGF | PEH0652 | Recombinant Human KGF | Human | 18.9 KDa |
| FGF-21 (N-6His) | PEH0651 | Recombinant Human FGF-21 (N-6His) | Human | 21.69 KDa |
| FGFb (146AA) | PEH0650 | Recombinant Human FGFb (146AA) | Human | 16.3 KDa |
| FGFb (155AA) | PEH0649 | Recombinant Human FGFb (155AA) | Human | 17.3 KDa |
| FGFb (157AA) | PEH0648 | Recombinant Human FGFb (157AA) | Human | 17.4 KDa |
| FGF-19 (N-6His) | PEH0646 | Recombinant Human FGF-19 (N-6His) | Human | 23.5 KDa |
| FGF-17 | PEH0645 | Recombinant Human FGF-17 | Human | 22.6 KDa |
| FGF-12 | PEH0644 | Recombinant Human FGF-12 | Human | 20.45 KDa |
| FGFa (140AA) | PEH0643 | Recombinant Human FGFa (140AA) | Human | 16 KDa |
| FGFa (154AA) | PEH0642 | Recombinant Human FGFa (154AA) | Human | 17.3 KDa |
Validation Data
Related Products
Super-sensitive ECL chemiluminescent reagent
References
1. Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance. Edirisinghe O, et al. Biomolecules. 2024. [PMID: 39766329]
2. FGF/FGFR signaling in health and disease. Xie Y, et al. Signal Transduct Target Ther. 2020. [PMID: 32879300]
3. Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. Wiedemann M, et al. Genomics. 2000. [PMID: 11031111]
4. Exploring mechanisms of FGF signalling through the lens of structural biology. Goetz R, et al. Nat Rev Mol Cell Biol. 2013. [PMID: 23403721]
5. Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting. Farrell B, et al. Biochem Soc Trans. 2018. [PMID: 30545934]
6. Canonical fibroblast growth factors in viral infection. Lottini G, et al. Rev Med Virol. 2023. [PMID: 37119022]