Colony Stimulating Factors (CSFs)
The colony-stimulating factor (CSF) family comprises soluble glycoproteins that govern the survival, proliferation and lineage-specific differentiation of hematopoietic progenitors while activating mature blood cells. Four major members are recognized: granulocyte-macrophage CSF (GM-CSF), macrophage CSF (M-CSF/CSF-1), granulocyte CSF (G-CSF) and multipotential CSF (IL-3). GM-CSF, G-CSF and M-CSF engage distinct α-chains coupled to either the common β-subunit (GM-CSFRβ) or LIFRβ, triggering JAK2-STAT5/3, PI3K-AKT and ERK cascades that promote myeloid commitment toward granulocytes, monocytes/macrophages or dendritic cells. Beyond hematopoiesis, CSFs contribute to embryo implantation, placental development, tissue repair and tumor microenvironment remodeling. Recombinant G-CSF (filgrastim) and GM-CSF (sargramostim) are standard of care for chemotherapy-induced neutropenia, stem-cell mobilization and immune augmentation, and are stockpiled for acute radiation syndrome, leukemia and adjuvant immunotherapy.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
M-CSF | Recombinant Rat M-CSF | Rat | 25.2 kDa | |
GM-CSF (C-6His) | Recombinant Rat GM-CSF (C-6His) | Rat | 15.6 kDa | |
EPO (C-6His) | Recombinant Mouse EPO (C-6His) | Mouse | 19.4 kDa | |
TPO (N-6His) | Recombinant Mouse TPO (N-6His) | Mouse | 36.4 kDa | |
TPO (C-6His) | Recombinant Mouse TPO (C-6His) | Mouse | 36.4 kDa | |
| M-CSF | PHM1141 | Recombinant Mouse M-CSF | Mouse | 26 kDa |
| M-CSF (C-6His) | PHM1125 | Recombinant Mouse M-CSF (C-6His) | Mouse | 27 kDa |
| G-CSF (C-6His) | PHM0758 | Recombinant Mouse G-CSF (C-6His) | Mouse | 19.8 kDa |
| GM-CSF (C-6His) | PHM0748 | Recombinant Mouse GM-CSF (C-6His) | Mouse | 15.1 kDa |
| TPO (N, C-6His) | PHH1637 | Recombinant Human TPO (N, C-6His) | Human | 37.3 kDa |
| M-CSF (C-6His) | PHH1139 | Recombinant Human M-CSF (C-6His) | Human | 26.17 kDa |
| GM-CSF (C-6His) | PHH0749 | Recombinant Human GM-CSF (C-6His) | Human | 15.5 kDa |
| EOP (C-6His) | PHH0605 | Recombinant Human EOP (C-6His) | Human | 19.2 kDa |
| GM-CSF | PEM0750 | Recombinant Mouse GM-CSF | Mouse | 14.2 kDa |
| GM-CSF (E. coli) | PEH0747 | Recombinant Human GM-CSF (E. coli) | Human | 14.6 kDa |
| G-CSF | PEH0720 | Recombinant Human G-CSF | Human | 18.8 kDa |
Validation Data
Recombinant Rat GM-CSF (C-6His) (Catalog: PHR0759) Recombinant Human EOP (C-6His) (Catalog: PHH0605)
Related Products
Super-sensitive ECL chemiluminescent reagent
References
1. Biology and action of colony--stimulating factor-1. Stanley ER, et al. Mol Reprod Dev.1997. [PMID: 8981357]
2. Recent advances of colony-stimulating factor-1 receptor (CSF-1R) kinase and its inhibitors. El-Gamal MI, et al. J Med Chem. 2018. [PMID: 29293000]
3. Colony-stimulating factor 1 receptor signaling in the central nervous system and the potential of its pharmacological inhibitors to halt the progression of neurological disorders. Tarale P, et al. Inflammopharmacology. 2022. [PMID: 35290551]