Interleukin Receptors (ILRs)
Interleukin Receptors (ILRs) are a family of transmembrane proteins widely expressed on the surface of immune and non-immune cells. Their core function is to specifically bind to interleukins (ILs) and initiate intracellular signal transduction, thereby regulating the body's immune response, cell proliferation and differentiation, as well as physiological and pathological processes. Currently, 38 identified interleukins (IL-1 to IL-38) all need to bind to corresponding ILRs to exert their effects, and the specific binding between the two is the primary step for the realization of interleukin functions.
Based on structural characteristics and signaling mechanisms, the ILRs family is mainly divided into four categories: The first category is the IL-17 receptor family, which includes five members (IL-17RA to IL-17RE). They mostly mediate pro-inflammatory and immune response signals in the form of complexes (e.g., IL-17RA/RC complex), and the conserved intracellular "SEFIR" domain is the key basis for signal transduction; The second category is Ig-like receptors, which belong to the immunoglobulin superfamily (IgSF) and contain 1-7 Ig-like domains. Typical members include IL-1 receptor and IL-18 receptor, which are widely involved in inflammation initiation and immune regulation; The third category is Type I receptors (also known as erythropoietin receptor family), most of which are composed of multiple subunits. Their extracellular region contains conserved cysteine residues and a WSXWS sequence (Trp-Ser-X-Trp-Ser), covering receptors for IL-2, IL-3, IL-6, etc., and regulating immune cell proliferation and hematopoiesis; The fourth category is Type II receptors (also known as interferon receptor family), whose extracellular region contains four conserved cysteine residues but no WSXWS sequence. They mostly exist as heterodimers, such as IL-10 and IL-22 receptors, and often bind to Janus kinases (JAK) to transmit anti-inflammatory or antiviral signals.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
| IL-2RG (C-Fc) | PHM0993 | Recombinant Mouse IL-2RG (C-Fc) | Mouse | 55.1 KDa |
| IL-1R2 (C-Fc) | PHM0977 | Recombinant Mouse IL-1R2 (C-Fc) | Mouse | 64.9 KDa |
| IL-1R2 (C-6His) | PHM0976 | Recombinant Mouse IL-1R2 (C-6His) | Mouse | 39 KDa |
| IL-15RA (C-Fc) | PHM0873 | Recombinant Mouse IL-15RA (C-Fc) | Mouse | 45.5 KDa |
| IL18R1 (C-6His) | PHH2417 | Recombinant Human IL18R1 (C-6His) | Human | 36.6 KDa |
| IL-15RA&IL-15 Complex (C-Fc) | PHH2394 | Recombinant Human IL-15RA&IL-15 Complex (C-Fc) | Human | 34.4&12.8 KDa |
| IL-1R2 (C-Fc) | PHH0979 | Recombinant Human IL-1R2 (C-Fc) | Human | 64.5 KDa |
| IL-1R2 (C-6His) | PHH0978 | Recombinant Human IL-1R2 (C-6His) | Human | 38.6 KDa |
| IL-2RG (C-Fc) | PHH0918 | Recombinant Human IL-2RG (C-Fc) | Human | 55.4 KDa |
| IL-22RA2 (C-Fc) | PHH0909 | Recombinant Human IL-22RA2 (C-Fc) | Human | 51.8 KDa |
| IL-22RA2 (C-6His) | PHH0908 | Recombinant Human IL-22RA2 (C-6His) | Human | 25.7 KDa |
| IL-20RB (C-Fc) | PHH0902 | Recombinant Human IL-20RB (C-Fc) | Human | 49.6 KDa |
| IL-20RA (C-Fc) | PHH0901 | Recombinant Human IL-20RA (C-Fc) | Human | 52.4 KDa |
| IL-20RA (C-6His) | PHH0900 | Recombinant Human IL-20RA (C-6His) | Human | 26.3 KDa |
| IL-1RAcP (Q9NPH3-2, C-Fc-6His) | PHH0893 | Recombinant Human IL-1RAcP (Q9NPH3-2, C-Fc-6His) | Human | 66.7 KDa |
| IL-1RAcP (Q9NPH3-2, C-6His) | PHH0892 | Recombinant Human IL-1RAcP (Q9NPH3-2, C-6His) | Human | 39.75 KDa |
| IL-15RA&IL-15 (C-Fc) | PHH0872 | Recombinant Human IL-15RA&IL-15 (C-Fc) | Human | 46.9 KDa |
| IL-15RA (C-Fc) | PHH0871 | Recombinant Human IL-15RA (C-Fc) | Human | 42.2 KDa |
| IL-10RB (C-Fc) | PHH0860 | Recombinant Human IL-10RB (C-Fc) | Human | 50.6 KDa |
| IL-10RB (C-6His) | PHH0859 | Recombinant Human IL-10RB (C-6His) | Human | 24.5 KDa |
| IL-1RA | PEM0894 | Recombinant Mouse IL-1RA | Mouse | 17.5 KDa |
| IL-1RA | PEH0891 | Recombinant Human IL-1RA | Human | 17.26 KDa |
Validation Data
Related Products
Super-sensitive ECL chemiluminescent reagent
References
1. TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity. Riva F, et al. Front Immunol. 2012. [PMCID: PMC3482685]
2. Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic Implications. Monin L, et al. Cold Spring Harb Perspect Biol. 2018. [PMID: 28620097]
3. Interleukin signaling. Vosshenrich CA, et al. Curr Biol. 2002. [PMID: 12445398]
4. Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. Akdis M, et al. J Allergy Clin Immunol. 2016. [PMID: 27577879]
