Product List

Recombinant Mouse GDF15 (N-8His-Flag)

Size1:10μg price1:$168
Size2:50μg price2:$465
Size3:500μg price3:$2325

SKU: PHM2405

Detail

Name	Recombinant Mouse GDF15 (N-8His-Flag)
Purity	Greater than 95% as determined by reducing SDS-PAGE
Endotoxin level	<1 EU/µg as determined by LAL test.
Construction	Recombinant Mouse Growth Differentiation Factor/xa015 is produced by our Mammalian expression system and the target gene encoding Ser189-Ala303 is expressed with a 8His, Flag tag at the N-terminus.
Accession #	Q9Z0J7
Host	Human cells
Species	Mouse
Predicted Molecular Mass	16.9 KDa
Buffer	Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
Form	Lyophilized
Shipping	The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
Stability&Storage	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Reconstitution	Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in 4mM HCl.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Alternative Names

Growth Differentiation Factor/xa015, Macrophage inhibitory cytokine 1, GDF-15, MIC-1, NAG-1, PLAB, PTGFB

Background

Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be secreted by a wide variety of cell types in response to a broad range of stressors. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. GDF15 was shown to inhibit proliferation of primitive hematopoietic progenitors and introduced as a putative placental mediator of embryonic development. GDF15 has recently gained scientific and translational prominence with the discovery that its receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain.

Note

For Research Use Only , Not for Diagnostic Use.